Evidence map›Paper›PMID 29719697›Full record

ArticleChemical science2018

Fabrication of microstructured binary polymer brush "corrals" with integral pH sensing for studies of proton transport in model membrane systems.

J Madsen, R E Ducker, O Al Jaf, M L Cartron, A M Alswieleh, C H Smith, C N Hunter, S P Armes, G J Leggett

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

J MadsenDepartment of Chemistry , University of Sheffield , Brook Hill , Sheffield S3 7HF , UK . Email: peterjeppemadsen@googlemail.com ; Email: s.p.armes@sheffield.ac.uk ; Email: Graham.Leggett@sheffield.ac.uk.ORCID 0000-0001-7625-9498
R E DuckerDepartment of Chemistry , University of Sheffield , Brook Hill , Sheffield S3 7HF , UK . Email: peterjeppemadsen@googlemail.com ; Email: s.p.armes@sheffield.ac.uk ; Email: Graham.Leggett@sheffield.ac.uk.
O Al JafDepartment of Chemistry , University of Sheffield , Brook Hill , Sheffield S3 7HF , UK . Email: peterjeppemadsen@googlemail.com ; Email: s.p.armes@sheffield.ac.uk ; Email: Graham.Leggett@sheffield.ac.uk.
M L CartronDepartment of Molecular Biology and Biotechnology , University of Sheffield , Western Bank , Sheffield S10 2TN , UK.
A M AlswielehKing Saud University , Riyadh , Saudi Arabia.
C H SmithDepartment of Chemistry , University of Sheffield , Brook Hill , Sheffield S3 7HF , UK . Email: peterjeppemadsen@googlemail.com ; Email: s.p.armes@sheffield.ac.uk ; Email: Graham.Leggett@sheffield.ac.uk.
C N HunterDepartment of Molecular Biology and Biotechnology , University of Sheffield , Western Bank , Sheffield S10 2TN , UK.ORCID 0000-0003-2533-9783
S P ArmesDepartment of Chemistry , University of Sheffield , Brook Hill , Sheffield S3 7HF , UK . Email: peterjeppemadsen@googlemail.com ; Email: s.p.armes@sheffield.ac.uk ; Email: Graham.Leggett@sheffield.ac.uk.ORCID 0000-0002-8289-6351
G J LeggettDepartment of Chemistry , University of Sheffield , Brook Hill , Sheffield S3 7HF , UK . Email: peterjeppemadsen@googlemail.com ; Email: s.p.armes@sheffield.ac.uk ; Email: Graham.Leggett@sheffield.ac.uk.ORCID 0000-0002-4315-9076
University of Sheffield · GBKing Saud University · SA

Funding

Biotechnology and Biological Sciences Research Council BB/M000265/1
6 · The paper itself

Abstract

Binary brush structures consisting of poly(cysteine methacrylate) (PCysMA) "corrals" enclosed within poly(oligoethylene glycol methyl ether methacrylate) (POEGMA) "walls" are fabricated simply and efficiently using a two-step photochemical process. First, the C-Cl bonds of 4-(chloromethyl)phenylsilane monolayers are selectively converted into carboxylic acid groups by patterned exposure to UV light through a mask and POEGMA is grown from unmodified chlorinated regions by surface-initiated atom-transfer radical polymerisation (ATRP). Incorporation of a ratiometric fluorescent pH indicator, Nile Blue 2-(methacryloyloxy)ethyl carbamate (NBC), into the polymer brushes facilitates assessment of local changes in pH using a confocal laser scanning microscope with spectral resolution capability. Moreover, the dye label acts as a radical spin trap, enabling removal of halogen end-groups from the brushes

Identifiers

PMID29719697
PMCPMC5897877
OpenAlexW2782937225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.