Evidence map›Paper›PMID 29719645›Full record

ArticleJournal of ophthalmic & vision research

Intravitreal Injection of Anti-vascular Endothelial Growth Factor Agents for Ocular Vascular Diseases: Clinical Practice Guideline.

Homayoun Nikkhah, Saeed Karimi, Hamid Ahmadieh, Mohsen Azarmina, Majid Abrishami, Hossein Ahoor, Yousef Alizadeh, Hasan Behboudi, Narsis Daftarian, Mohammad Hossein Dehghan and 25 more

Open access · goldAbstract read
In one paragraph

Article in Journal of ophthalmic & vision research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 14 institutions in 1 country.

Homayoun NikkhahOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeed KarimiOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamid AhmadiehOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohsen AzarminaOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Majid AbrishamiDepartment of Ophthalmology, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein AhoorDepartment of Ophthalmology, Tabriz University of Medical Sciences, Tabriz, Iran.
Yousef AlizadehDepartment of Ophthalmology, Guilan University of Medical Sciences, Rasht, Iran.
Hasan BehboudiDepartment of Ophthalmology, Guilan University of Medical Sciences, Rasht, Iran.
Narsis DaftarianOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Hossein DehghanDepartment of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Morteza EntezariOphthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fereydoun FarrahiDepartment of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Heshmatollah GhanbariDepartment of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Khalil Ghasemi FalavarjaniDepartment of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Ali JavadiOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza KarkhanehDepartment of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Siamak MoradianOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Masoud Reza ManaviatDepartment of Ophthalmology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Morsal MehryarDepartment of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
Ramin NouriniaOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Mehdi ParvareshDepartment of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Alireza RamezaniOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza Ragati HaghiDepartment of Ophthalmology, Razavi Hospital, Mashhad, Iran.
Mohammad Riazi-EsfahaniDepartment of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Masoud SoheilianOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohsen ShahsavariDepartment of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein-Ali ShahriariDepartment of Ophthalmology, Al-Zahra Eye Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Zhale RajaviOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sare SafiDepartment of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Armin ShirvaniStandardization and CPG Development Office, Deputy of Curative Affairs, Ministry of Health and Medical Education, Tehran, Iran.
Saeed RahmaniOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamideh SabbaghiOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojgan PakbinOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahareh KheiriOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein ZiaeiOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences · IRGuilan University of Medical Sciences · IRTehran University of Medical Sciences · IRAhvaz Jundishapur University of Medical Sciences · IREmam Reza Hospital · IRIran University of Medical Sciences · IRIsfahan University of Medical Sciences · IRMashhad University of Medical Sciences · IRMinistry of Health and Medical Education · IRRasool Akram Hospital · IRShahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IRTabriz University of Medical Sciences · IRZahedan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo provide the clinical recommendations for the administration of intravitreal anti-vascular endothelial growth factor (VEGF) drugs especially bavacizumab for ocular vascular diseases including diabetic macular edema, neovascular age-related macular degeneration, myopic choroidal neovascularization, retinal vein occlusion and central serous chorioretinopathy.

methodsTwenty clinical questions were developed by the guideline technical committee. Relevant websites and databases were searched to find out the pertinent clinical practice guidelines to answer the questions. The technical committee provided possible answers (scenarios) according to the available evidences for each question. All scenarios along with their levels of evidence and the supported articles were sent to the experts for external review. If the experts did not agree on any of the scenarios for one particular clinical question, the technical committee reviewed all scenarios and their pertinent evidences and made the necessary decision. After that, the experts were asked to score them again. All confirmed scenarios were gathered as the final recommendations.

resultsAll the experts agreed on at least one of the scenarios. The technical committee extracted the agreed scenario for each clinical question as the final recommendation. Finally, 56 recommendations were developed for the procedure of intravitreal anti-VEGF injection and their applications in the management of ocular vascular diseases.

conclusionThe implementation of this guideline can standardize the management of the common ocular vascular diseases by intravitreal injection of anti-VEGF agents. It can lead to better policy-making and evidence-based clinical decision by ophthalmologists and optimal evidence based eye care for patients.

Indexed as

Age-related Macular DegenerationAnti-vascular Endothelial Growth FactorDiabetic Macular EdemaIntravitreal InjectionRetinal Vein Occlusion

Identifiers

PMID29719645
PMCPMC5905310
OpenAlexW2797981803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.