Evidence map›Paper›PMID 29719628›Full record

ArticleOncotarget2018

Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets

Elena I Fedoros, Alexey A Orlov, Alexander Zherebker, Ekaterina A Gubareva, Mikhail A Maydin, Andrey I Konstantinov, Konstantin A Krasnov, Ruben N Karapetian, Ekaterina I Izotova, Sergey E Pigarev and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Elena I FedorosN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg 197758, Russia.
Alexey A OrlovDepartment of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Alexander ZherebkerDepartment of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Ekaterina A GubarevaN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg 197758, Russia.
Mikhail A MaydinN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg 197758, Russia.
Andrey I KonstantinovDepartment of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Konstantin A KrasnovInstitute of Toxicology, Federal Medical-Biological Agency, Saint-Petersburg 192019, Russia.
Ruben N KarapetianCHEMDIV LTD, Moscow District, Khimki 141400, Russia.
Ekaterina I IzotovaNobel LTD, Saint-Petersburg 192012, Russia.
Sergey E PigarevNobel LTD, Saint-Petersburg 192012, Russia.
Andrey V PanchenkoN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg 197758, Russia.
Margarita L TyndykN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg 197758, Russia.
Dmitry I OsolodkinInstitute of Poliomyelitis and Viral Encephalitides, Chumakov FSC R&D IBP RAS, Moscow 108819, Russia.
Evgeny N NikolaevSkolkovo Institute of Science and Technology, Skolkovo 143025, Russia.
Irina V PerminovaDepartment of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia.
Vladimir N AnisimovN.N. Petrov National Medical Research Center of Oncology, Saint-Petersburg 197758, Russia.
Institute of Oncology NN Petrov · RULomonosov Moscow State University · RUChumakov Institute of Poliomyelitis and Viral Encephalitides · RUFederal Medical-Biological Agency · RUInstitute of Energy Problems of Chemical Physics · RUSkolkovo Institute of Science and Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of molecular targets and mechanism of action is always a challenge, in particular - for natural compounds due to inherent chemical complexity. BP-Cx-1 is a water-soluble modification of hydrolyzed lignin used as the platform for a portfolio of innovative pharmacological products aimed for therapy and supportive care of oncological patients. The present study describes a new approach, which combines

Indexed as

BP-Cx-1cancerChEMBLmolecular targetspolyphenols

Identifiers

PMID29719628
PMCPMC5915095
OpenAlexW2795666525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.