Evidence map›Paper›PMID 29719609›Full record

ArticleOncotarget2018

Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway.

Paul Takam Kamga, Giada Dal Collo, Giulio Bassi, Martina Midolo, Massimo Delledonne, Marco Chilosi, Massimiliano Bonifacio, Mauro Krampera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul Takam KamgaStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy.
Giada Dal ColloStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy.
Giulio BassiStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy.
Martina MidoloStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy.
Massimo DelledonneDepartment of Biotechnology, University of Verona, Verona, Italy.
Marco ChilosiSection of Pathology, Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Massimiliano BonifacioStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy.
Mauro KramperaStem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, Verona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notch signaling contribution to B-cell acute lymphoblastic leukemia (B-ALL) development is still under investigation. The serendipitous onset of B-ALL in a patient affected by the germinal Notch mutation-dependent Alagille syndrome allowed us to establish a B-ALL cell line (VR-ALL) bearing a genetic loss of function in components of Notch signaling. VR-ALL is a common-type B-ALL cell line, grows in conventional culture medium supplemented with 10% serum, and gives rise, once injected into immunodeficient NOG mice, to a mouse xenograft model of B-ALL. Exome sequencing revealed deleterious mutations in some components of Notch signaling, including Jagged1, Notch1, and Notch2. In addition, VR-ALL is sensitive both

Indexed as

Alagille syndromeALGSB-acute lymphoblastic leukemiaB-ALLNotch signaling

Identifiers

PMID29719609
PMCPMC5915076

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.