Evidence map›Paper›PMID 29719445›Full record

ReviewThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2018

Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection.

Lovedeep Singh, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh Jaggi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lovedeep SinghDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Ritu KulshresthaVallabhbhai Patel Chest Institute, New Delhi 110007, India.
Nirmal SinghDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Amteshwar Singh JaggiDepartment of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury. These mechanisms include activation of K

Indexed as

AdenosineKATP channelsKinasesPreconditioningTRPV

Identifiers

PMID29719445
PMCPMC5928336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.