Evidence map›Paper›PMID 29719418›Full record

ArticleJournal of pain research2018

Assessment of synchronous neural activities revealed by regional homogeneity in individuals with acute eye pain: a resting-state functional magnetic resonance imaging study.

Li-Yuan Tang, Hai-Jun Li, Xin Huang, Jing Bao, Zubin Sethi, Lei Ye, Qing Yuan, Pei-Wen Zhu, Nan Jiang, Gui-Ping Gao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Li-Yuan Tang *Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Hai-Jun Li *Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xin HuangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Jing BaoDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zubin SethiThe Department of Medicine, University of Miami, Coral Gables, FL, USA.
Lei YeDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Qing YuanDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Pei-Wen ZhuDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Nan JiangDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Gui-Ping GaoDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Yi ShaoDepartment of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Nanchang University · CNUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious neuroimaging studies have demonstrated that pain-related diseases are associated with brain function and anatomical abnormalities, whereas altered synchronous neural activity in acute eye pain (EP) patients has not been investigated. The purpose of this study was to explore whether or not synchronous neural activity changes were measured with the regional homogeneity (ReHo) method in acute EP patients.

methodsA total of 20 patients (15 males and 5 females) with EP and 20 healthy controls (HCs) consisting of 15 and 5 age-, sex-, and education-matched males and females, respectively, underwent resting-state functional magnetic resonance imaging. The ReHo method was applied to assess synchronous neural activity changes.

resultsCompared with HCs, acute EP patients had significantly lower ReHo values in the left precentral/postcentral gyrus (Brodmann area [BA]3/4), right precentral/postcentral gyrus (BA3/4), and left middle frontal gyrus (BA6). In contrast, higher ReHo values in acute EP patients were observed in the left superior frontal gyrus (BA11), right inferior parietal lobule (BA39/40), and left precuneus (BA7). However, no relationship was found between the mean ReHo signal values of the different areas and clinical manifestations, which included both the duration and degree of pain in EP patients.

conclusionOur study highlighted that acute EP patients showed altered synchronous neural activities in many brain regions, including somatosensory regions. These findings might provide useful information for exploration of the neural mechanisms underlying acute EP.

Indexed as

acute eye paincorneal painfunctional magnetic resonance imagingregional homogeneityresting state

Identifiers

PMID29719418
PMCPMC5916265
OpenAlexW2802184741

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.