Evidence map›Paper›PMID 29719392›Full record

ArticleInternational journal of nanomedicine2018

Evaluation of the potential of a simplified co-delivery system with oligodeoxynucleotides as a drug carrier for enhanced antitumor effect.

Chunxi Liu, Tingxian Liu, Yongjun Liu, Na Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunxi Liu *Department of Pharmacy, Qilu Hospital, Shandong University, Ji'nan, China.
Tingxian Liu *School of Pharmaceutical Science, Shandong University, Ji'nan, China.
Yongjun LiuSchool of Pharmaceutical Science, Shandong University, Ji'nan, China.
Na ZhangSchool of Pharmaceutical Science, Shandong University, Ji'nan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously developed a simple effective system based on oligodeoxynucleotides with CGA repeating units (CGA-ODNs) for Dox and siRNA intracellular co-delivery.

methodsIn the present study, the in vitro cytotoxicity, gene transfection and in vivo safety of the co-delivery system were further characterized and discussed.

resultsCompared with poly(ethyleneimine) (PEI), both CGA-ODNs and the pH-sensitive targeted coating,

conclusionThe results indicated that CPN-PDR could be a potentially promising co-delivery carrier for enhanced antitumor therapy.

Indexed as

AnimalsAntineoplastic AgentsChitosanDoxorubicinDrug CarriersDrug Delivery SystemsEndosomesHumansHydrogen-Ion ConcentrationMCF-7 CellsMiceNanoparticlesOligodeoxyribonucleotidesOligopeptidesPolyethylene GlycolsRNA, Small InterferingAntineoplastic AgentsChitosanDoxorubicinDrug CarriersNGR peptideO-carboxymethylchitosanOligodeoxyribonucleotidesOligopeptidesPolyethylene GlycolsRNA, Small Interferingco-deliverycytotoxicitydoxorubicintransfectionVEGF

Identifiers

PMID29719392
PMCPMC5916381

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.