ArticleShanghai archives of psychiatry2018
Neuropsychiatric Symptoms Induced by Large Doses of Nitrous Oxide Inhalation: A Case Report.
Article in Shanghai archives of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A Systematic Review of Recreational Nitrous Oxide Use: Implications for Policy, Service Delivery and Individuals.International journal of environmental research and public health · 2022Pooled it
- Nitrous Oxide-Induced Pancytopenia and Peripheral Neuropathy From Chronic Whip-It™ Use: A Case Report.Cureus · 2026Article
- Nitric oxide inhibition ameliorates cortical proteomic changes in the Cntnap2Molecular autism · 2026Article
- Posterior Reversible Encephalopathy Syndrome Following Recreational Nitrous Oxide Use: A Case Report.Cureus · 2026Article
- Soft Palate and Uvula Thermal Burn Injury in an Adolescent Following Recreational Inhalation of Nitrous Oxide.Cureus · 2025Article
- Acute psychotic and vitamin B12 deficiency in patient with nitrous oxide misuse: A case report.SAGE open medical case reports · 2024Article
- Nitrous oxide-induced neurotoxicity: Clinical characteristics and impacts on overall neurological impairments.Frontiers in neurology · 2023Article
- Update on Toxic Neuropathies.Current treatment options in neurology · 2022Article
- SPECT findings on neuropsychiatric symptoms caused by nitrous oxide abuse.Frontiers in psychiatry · 2022Article
- Nitrous oxide-related neurological disorders: Clinical, laboratory, neuroimaging, and electrophysiological findings.Brain and behavior · 2021Article
- Recreational Nitrous Oxide Abuse: Prevalence, Neurotoxicity, and Treatment.Neurotoxicity research · 2021Review
- Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders.Neuropsychiatric disease and treatment · 2020Article
- One month of nitrous oxide abuse causing acute vitamin BBMJ case reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrous Oxide, which is also called laughing gas, now ranks as the 7th most popular drug in the world. Nitrous oxide mainly disturbs B12 metabolism and damages nerves, followed by apparent neuropsychiatric symptoms. It's beneficial to the prognosis of patients if we identify and treat their symptoms early. This case report describes a 19-year-old male who presented with auditory hallucination, persecutory delusions and unstable emotions after abuse of nitrous oxide over the course of half a year. Moreover, neurological signs such as weakness and hyperesthesia also appeared. After supplementation of vitamin B12, the neuropsychiatric symptoms improved, while the lower extremities achieved partial recovery. Therapeutically, we should pay attention to nerve repair, motivation enhancement and reinforce interventions that prevent relapse.
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