ArticleShanghai archives of psychiatry2017
CHN2 Promoter Methylation Change May Be Associated With Methamphetamine Dependence.
Article in Shanghai archives of psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Decoding Encoded Cravings: Epigenetic Drivers of Addiction.Brain sciences · 2025Review
- Determining the diagnostic cut-off on the Chinese version of severity of dependence scale for DSM-5 stimulant use disorder.Frontiers in psychiatry · 2025Article
- Research progress of DNA methylation on the regulation of substance use disorders and the mechanisms.Frontiers in cellular neuroscience · 2025Review
- Epigenome-wide association study on methamphetamine dependence.Addiction biology · 2024Article
- An update: epigenetic mechanisms underlying methamphetamine addiction.Frontiers in cell and developmental biology · 2024Review
- Functional modular networks identify the pivotal genes associated with morphine addiction and potential drug therapies.BMC anesthesiology · 2023Article
- Review
- Genome-wide association study of stimulant dependence.Translational psychiatry · 2021Article
- Genome-Wide DNA Methylation Analysis in Male Methamphetamine Users With Different Addiction Qualities.Frontiers in psychiatry · 2020Article
- Article
- Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMethamphetamine (MA) abuse is becoming increasingly serious in China. The mechanism of MA dependence remains unclear. CHN2 gene encodes chimeric protein-2 that regulate axonal pruning via the Rac-GTPase system and play a pivotal role in the formation of nervous circuits. Genetic studies suggest that the polymorphism of the CHN2 gene was related to substance dependence.
aimsThe aim of this study was to investigate the association between the methylation of CHN2 gene promoter with MA dependence.
methodsAccording to SCID-I (Structured Clinical Interview for DSM-IV Axis I Disorders, SCID-I) used for investigating MA dependence, 224 male MA addicts were recruited into the case group. In addition, 109 healthy men were recruited into the control group. Blood samples were collected with the purpose of detecting the methylation levels of CHN2 gene promoter by methylight qPCR. The association between the methylation of CHN2 gene promoter with MA dependence was analyzed.
resultsThe mean (sd) methylation levels of CHN2 gene promoter in the case group were significantly higher than in the control group, which were 2795.55 (733.19) and 1026.73 (698.73), respectively, showing significant differences between the two groups (t=21.25, p<0.001). Pearson analysis showed no significant correlation between the methylation levels of CHN2 promoter and other factors (the age of initial MA use, the duration of MA use, combination with K powder, tobacco and alcohol).
conclusionsThe abnormal methylation of CHN2 gene promoter was significantly correlated with MA dependence.
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