Evidence map›Paper›PMID 29719253›Full record

ArticleCell reports2018

An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Ca

Wilnelly Martinez-Ortiz, Timothy J Cardozo

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. CL-705G: a novel chemical Kir6.2-specific KFrontiers in pharmacology · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. CaChannels (Austin, Tex.) · 2020
    Review
  8. Article
  9. Palmitoylation of the KProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wilnelly Martinez-OrtizDepartment of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.
Timothy J CardozoDepartment of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA. Electronic address: timothy.cardozo@nyumc.org.
NYU Langone Health · US

Funding

Chemical Biology Design For MalariaDP2OD004631 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARDOZO, TIMOTHY J · 2008 to 2014
$3.1M
Characterizing the Polyclonal Scope of Pathogenic anti-Ro AntibodiesF31HL124898 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARTINEZ-ORTIZ, WILNELLY · 2014 to 2018
$163k
NHLBI NIH HHS F31 HL124898NIH HHS DP2 OD004631
6 · The paper itself

Abstract

Voltage-gated ion channels (VGICs) are associated with hundreds of human diseases. To date, 3D structural models of human VGICs have not been reported. We developed a 3D structural integrity metric to rank the accuracy of all VGIC structures deposited in the PDB. The metric revealed inaccuracies in structural models built from recent single-particle, non-crystalline cryo-electron microscopy maps and enabled the building of highly accurate homology models of human Ca

Indexed as

Models, MolecularMutationHumansLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsProtein DomainsLarge-Conductance Calcium-Activated Potassium Channel alpha Subunits3D structuresCa(v) human channelscryoelectron microscopydisease-causing mutationshomology modelsstructure-activity-relationships and structure accuracy metricvoltage-gated ion channelsα(1) subunit

Identifiers

PMID29719253
PMCPMC5957504
OpenAlexW2801148359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.