Evidence map›Paper›PMID 29719243›Full record

ArticleCell reports2018

Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses.

Andreas Fulterer, Till F M Andlauer, Anatoli Ender, Marta Maglione, Katherine Eyring, Jennifer Woitkuhn, Martin Lehmann, Tanja Matkovic-Rachid, Joerg R P Geiger, Alexander M Walter and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Imaging Synapse Ultrastructure and Organization with STED Microscopy.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. Article
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  10. CaeLife · 2024
    Article
  11. CabioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Presynaptic Cytomatrix Proteins.Advances in neurobiology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Andreas FultererInstitute for Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany.
Till F M AndlauerMax Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Anatoli EnderGerman Center for Neurodegenerative Disorders, Charité Universitätsmedizin Berlin, 10117 Berlin, Germany.
Marta MaglioneInstitute for Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Katherine EyringNeuroscience Institute, NYU School of Medicine, New York, NY 10016, USA.
Jennifer WoitkuhnInstitute for Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany.
Martin LehmannLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Tanja Matkovic-RachidInstitute for Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany.
Joerg R P GeigerNeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany; Institut für Neurophysiologie, Charité Universitätsmedizin, 10117 Berlin, Germany.
Alexander M WalterLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Katherine I NagelNeuroscience Institute, NYU School of Medicine, New York, NY 10016, USA. Electronic address: katherine.nagel@nyumc.org.
Stephan J SigristInstitute for Biology/Genetics, Freie Universität Berlin, 14195 Berlin, Germany; NeuroCure Cluster of Excellence, Charité Universitätsmedizin, 10117 Berlin, Germany. Electronic address: stephan.sigrist@fu-berlin.de.
Charité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DELeibniz-Forschungsinstitut für Molekulare Pharmakologie · DENeurosciences Institute · USGerman Center for Neurodegenerative Diseases · DETechnical University of Munich · DE

Funding

The role of short-term synaptic plasticity in sensory processing and behaviorR01MH109690 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NAGEL, KATHERINE · 2016 to 2020
$2.0M
NIMH NIH HHS R01 MH109690
6 · The paper itself

Abstract

High-throughput electron microscopy has started to reveal synaptic connectivity maps of single circuits and whole brain regions, for example, in the Drosophila olfactory system. However, efficacy, timing, and frequency tuning of synaptic vesicle release are also highly diversified across brain synapses. These features critically depend on the nanometer-scale coupling distance between voltage-gated Ca

Indexed as

Mushroom BodiesSynaptic VesiclesAnimalsDrosophila melanogasterDrosophila ProteinsGTPase-Activating ProteinsMembrane ProteinsNerve Tissue ProteinsBRP protein, DrosophilaDrosophila ProteinsGTPase-Activating ProteinsMembrane ProteinsNerve Tissue ProteinsRhoGAP100F protein, Drosophilaunc-13 protein, Drosophilaactive zoneBruchpilotDrosophilamunc13nanoscopyneurotransmitter releaseolfactory systempositional primingSyd-1synapse diversitysynapse physiology

Identifiers

PMID29719243
PMCPMC6436828
OpenAlexW2799399472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.