Evidence map›Paper›PMID 29719227›Full record

ArticleCell metabolism2018

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

Marcus M Seldin, Simon Koplev, Prashant Rajbhandari, Laurent Vergnes, Gregory M Rosenberg, Yonghong Meng, Calvin Pan, Thuy M N Phuong, Raffi Gharakhanian, Nam Che and 17 more

Open access · bronzeAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
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  7. SALVE: prediction of interorgan communication with transcriptome latent space representation.American journal of physiology. Heart and circulatory physiology · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 4 countries.

Marcus M SeldinDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Simon KoplevDepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.
Prashant RajbhandariDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Laurent VergnesDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Gregory M RosenbergDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yonghong MengDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Calvin PanDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Thuy M N PhuongDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Raffi GharakhanianDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nam CheDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Selina MäkinenDepartment of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland.
Diana M ShihDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Mete CivelekDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Brian W ParksDepartment of Nutritional Sciences, University of Wisconsin, Madison, WI, USA.
Eric D KimDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Frode NorheimDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Karthickeyan Chella KrishnanDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yehudit Hasin-BrumshteinDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Margarete MehrabianDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Christian A DrevonDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Heikki A KoistinenDepartment of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland.
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Karen ReueDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Rita M CantorDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.
Aldons J LusisDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA. Electronic address: jlusis@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Oslo · NOIntegrated Cardio Metabolic Centre · SEKarolinska University Hospital · SEKuopio University Hospital · FIMinerva Foundation · FIUniversity of Helsinki · FIUniversity of Virginia · USUniversity of Wisconsin–Madison · US

Funding

ULTRASTRUCTURE OF THE INTIMA IN EARLY LESION FORMATIONP01HL030568 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FOGELMAN, ALAN M · 1985 to 2019
$55.2M
Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Systems genetics analysis of cardiometabolic trait loci in humans R00HL121172 · NHLBI · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE · 2016 to 2018
$741k
NHLBI NIH HHS P01 HL028481NHLBI NIH HHS P01 HL030568NHLBI NIH HHS R00 HL121172NHLBI NIH HHS T32 HL007895NHLBI NIH HHS T32 HL069766
6 · The paper itself

Abstract

Inter-tissue communication via secreted proteins has been established as a vital mechanism for proper physiologic homeostasis. Here, we report a bioinformatics framework using a mouse reference population, the Hybrid Mouse Diversity Panel (HMDP), which integrates global multi-tissue expression data and publicly available resources to identify and functionally annotate novel circuits of tissue-tissue communication. We validate this method by showing that we can identify known as well as novel endocrine factors responsible for communication between tissues. We further show the utility of this approach by identification and mechanistic characterization of two new endocrine factors. Adipose-derived Lipocalin-5 is shown to enhance skeletal muscle mitochondrial function, and liver-secreted Notum promotes browning of white adipose tissue, also known as "beiging." We demonstrate the general applicability of the method by providing in vivo evidence for three additional novel molecules mediating tissue-tissue interactions.

Indexed as

HomeostasisAdipose TissueAnimalsCells, CulturedEndocrine SystemLipocalinsMiceMice, Inbred C57BLMitochondriaMitochondrial ProteinsMuscle, SkeletalProteomicsLipocalinsMitochondrial Proteinsadipocyte beigingcross-tissue communicationendocrineinter-alpha-trypsin inhibitor heavy chain H5Lipocalin-5mitochondriaNotumpro-platelet basic proteinsecreted peptidesskeletal muscle respirationSPARC-related modular calcium binding 1

Identifiers

PMID29719227
PMCPMC5935137
OpenAlexW2800349415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.