ArticleCell metabolism2018
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 1 pooled it
23.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
245 citing papers in PubMed, 1 synthesis or guideline pooled it, 360 citations in OpenAlex.
- Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review.Frontiers in immunology · 2025Pooled it
- Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.The Journal of clinical endocrinology and metabolism · 2023Trial
- Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.Journal of the International Society of Sports Nutrition · 2021Trial
- Design and Exploration of a Tricyclic Series of CNS-Penetrant CD38 Small Molecule Inhibitors.ACS medicinal chemistry letters · 2026Article
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- A Mechanism-Based Framework for Anti-Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell-Based Interventions.Aging cell · 2026Review
- CD38-activated macrophages drive age-related placental senescence by depleting NADNature communications · 2026Article
- CD38 Inhibition Enhances FXR Signaling in Male Rats With Diabetic Steatohepatitis Through SIRT1-Dependent Suppression of NLRP3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026Review
- Emerging chemical strategies for CD38 inhibition: restoring NADBioorganic & medicinal chemistry · 2026Review
- Inhibition of CD38 by 78c Enhanced NADInternational journal of molecular sciences · 2026Article
- Placental nicotinamide adenine dinucleotide modulates the timing of labor.Science (New York, N.Y.) · 2026Article
- Circulating CD38 shows stronger association with incident heart failure in women despite lower levels: sex differences and kidney-function context.Biology of sex differences · 2026Article
- Activating the vagus nerve-adrenal anti-inflammatory axis to delay aging: A randomized controlled trial protocol.Contemporary clinical trials communications · 2026Article
- Differential regulation of monocyte exhaustion by distinct TLR agonists and underlying mechanisms.Cell communication and signaling : CCS · 2026Article
- Review
- Epigenetic Age Acceleration Is Associated With HIV Infection Independently of Inflammation.Open forum infectious diseases · 2026Article
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Endothelial NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration.Aging cell · 2026 · on this mapArticle
185 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Mariana G TarragóSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Claudia C S ChiniSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Karina S KanamoriSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Gina M WarnerSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Ariel CarideSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Guilherme C de OliveiraSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Micaela RudSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Adrienne SamaniDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Kyaw Z HeinSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA.
Runqing HuangKogod Aging Center, Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Diana JurkInstitute for Cell and Molecular Biosciences and Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE 4 5PL, UK.
Dong Seong ChoDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
James J BoslettRadiology and Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Jordan D MillerKogod Aging Center, Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Jay L ZweierRadiology and Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
João F PassosInstitute for Cell and Molecular Biosciences and Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne NE 4 5PL, UK.
Jason D DolesDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
David J BechererViamet Pharmaceuticals, Inc., 4505 Emperor Boulevard, Suite 300, Durham, NC 27703, USA.
Eduardo N ChiniSignal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, 222 3rd Avenue SW, Rochester, MN 55905, USA. Electronic address: chini.eduardo@mayo.edu.
Mayo Clinic · USWinnMed · USMayo Clinic in Arizona · USNewcastle University · GBThe Ohio State University · USViamet Pharmaceuticals (United States) · US
Funding
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI MUKHOPADHYAY, DEBABRATA · 2004 to 2018
$32.7MPILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Nicholas F. LaRusso · 2009 to 2026
$22.2MRole of Cytoglobin in the Regulation of Vascular ToneR01HL131941 · NHLBI · OHIO STATE UNIVERSITY · PI JAY Louis ZWEIER · 2017 to 2026
$5.7MThe Sir2-p53-IGF Link in Mammalian Life-Span ControlR01AG026094 · NIA · UNIVERSITY OF VIRGINIA · PI CHINI, EDUARDO N · 2006 to 2016
$3.8MMechanisms of Nicotine Inhalation-Induced Cardiovascular DiseaseR01HL135648 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2017 to 2021
$2.6MRole of senescent cells in the pathogenesis of Marfan-associated cardiovascular diseaseR01HL141819 · NHLBI · MAYO CLINIC ROCHESTER · PI MILLER, JORDAN D · 2018 to 2021
$1.6MRole of Vav1 protooncogene in pancreatic cancerP20CA102701 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI PETERSEN, GLORIA M. · 2003 to 2003
$1.5MPost-transcriptional Regulation of Satellite Cell FunctionR00AR066696 · NIAMS · MAYO CLINIC ROCHESTER · PI DOLES, JASON · 2016 to 2018
$961kPost-transcriptional Regulation of Satellite Cell FunctionK99AR066696 · NIAMS · UNIVERSITY OF COLORADO · PI DOLES, JASON · 2015 to 2015
$93kArthritis Research UKBiotechnology and Biological Sciences Research Council BB/K017314/1Medical Research Council MR/L016354/1NCI NIH HHS P20 CA102701NCI NIH HHS P50 CA102701NHLBI NIH HHS R01 HL131941NHLBI NIH HHS R01 HL135648NHLBI NIH HHS R01 HL141819NIAMS NIH HHS K99 AR066696NIAMS NIH HHS R00 AR066696NIA NIH HHS R01 AG026094NIDDK NIH HHS P30 DK084567
Abstract
Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide (NAD
Indexed as
ADP-ribosyl Cyclase 1AgingAMP-Activated Protein Kinase KinasesAnimalsCellular SenescenceDNA DamageEnzyme InhibitorsGlucose IntoleranceHumansMAP Kinase Signaling SystemMiceNADPhysical Functional PerformancePoly(ADP-ribose) PolymerasesProtein KinasesQuinolinesADP-ribosyl Cyclase 1AMP-Activated Protein Kinase KinasesEnzyme InhibitorsmTOR protein, mouseNADPoly(ADP-ribose) PolymerasesProtein KinasesQuinolinesSirtuinsTOR Serine-Threonine KinasesTriazolesacetylationagingCD38exercise capacityglucoseNAD(+)progeroidSIRTUINSskeletal muscle
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.