ArticleCell metabolism2018
NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes.
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Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
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Who cites it
49 citing papers in PubMed, 67 citations in OpenAlex.
- Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency.Diabetologia · 2025Trial
- GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Partial replacement of soybean meal with vitamin BAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Global knockout of VEGFB improves lipoprotein lipase activity leading to an improved lipid profile during diabetes.Frontiers in pharmacology · 2026Article
- Extracellular Vesicles From Chylomicron-Treated Endothelial Cells Drive Macrophage Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- GPIHBP1, lipoprotein lipase, and triglyceride-rich lipoproteins in capillaries of the choroid plexus and circumventricular organs.The Journal of clinical investigation · 2025Article
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- Distinct strategies for intravascular triglyceride metabolism in hearts of mammals and lower vertebrate species.JCI insight · 2024Article
- Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications.Angiogenesis · 2024Article
- In the Beginning, Lipoproteins Cross the Endothelial Barrier.Journal of atherosclerosis and thrombosis · 2024Review
- Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk.The FEBS journal · 2024Review
- Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice.The Journal of clinical investigation · 2024Article
- Lipoprotein lipase as a target for obesity/diabetes related cardiovascular disease.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024Review
- Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.Science (New York, N.Y.) · 2023Article
- The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels.Nature communications · 2023Article
- The Link between Magnesium Supplements and Statin Medication in Dyslipidemic Patients.Current issues in molecular biology · 2023Review
- Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Endothelial Lipid Metabolism.Cold Spring Harbor perspectives in medicine · 2022Review
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Authors and funding
18 authors at 4 institutions in 3 countries.
Cuiwen HeDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Thomas A WestonDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Rachel S JungDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Patrick HeizerDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mikael LarssonDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xuchen HuDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Christopher M AllanDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Peter TontonozDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Karen ReueDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Anne P BeigneuxDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michael PlougFinsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Andrea HolmeCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
Matthew KilburnCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
Paul GuagliardoCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
David A FordDepartment of Biochemistry and Molecular Biology, Center for Cardiovascular Research, Saint Louis University, St. Louis, MO 63104, USA.
Loren G FongDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Stephen G YoungDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sgyoung@mednet.ucla.edu.
Haibo JiangDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia. Electronic address: haibo.jiang@uwa.edu.au.
University of California, Los Angeles · USUniversity of Western Australia · AUSaint Louis University · USUniversity of Copenhagen · DK
Funding
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9MThe Lipin Protein Family and Triglyceride Metabolism P01HL090553 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2008 to 2018
$23.3MUnderstanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2019 to 2023
$11.7MRefining Physiologic Mechanisms for Intravascular Triglyceride MetabolismR01HL087228 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEIGNEUX, ANNE, FONG, LOREN GI · 2007 to 2024
$7.8MVascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4MInvestigating Mechanisms for Lipid Transport in Health and DiseaseR35HL139725 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2018 to 2024
$6.1MDefining mechanisms for lipid transport across capillary endothelial cellsR01HL125335 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2015 to 2017
$1.2MInvestigation of lipid transport using NanoSIMS and backscattered electron imagingF32HL132471 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HE, CUIWEN · 2016 to 2018
$168kHoward Hughes Medical InstituteNHLBI NIH HHS F32 HL132471NHLBI NIH HHS P01 HL090553NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R01 HL087228NHLBI NIH HHS R01 HL125335NHLBI NIH HHS R35 HL139725NHLBI NIH HHS T32 HL069766
Abstract
The processing of triglyceride-rich lipoproteins (TRLs) in capillaries provides lipids for vital tissues, but our understanding of TRL metabolism is limited, in part because TRL processing and lipid movement have never been visualized. To investigate the movement of TRL-derived lipids in the heart, mice were given an injection of [
Indexed as
LipolysisAnimalsCapillariesCD36 AntigensDeuteriumEndothelial CellsLipid DropletsLipoproteinsMiceMice, Inbred C57BLMitochondriaMyocytes, CardiacSpectrometry, Mass, Secondary IonTriglyceridesCD36 AntigensDeuteriumLipoproteinslipoprotein triglycerideTriglycerideschylomicronselectron microscopyfatty acidslipoprotein lipaseNanoSIMStriglycerides
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