Evidence map›Paper›PMID 29719216›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Hybrid nanoparticle-based nicotine nanovaccines: Boosting the immunological efficacy by conjugation of potent carrier proteins.

Zongmin Zhao, Yun Hu, Theresa Harmon, Paul R Pentel, Marion Ehrich, Chenming Zhang

Abstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. NICBrain sciences · 2025
    Article
  3. Article
  4. Article
  5. Nanoparticle delivery systems for substance use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. The impact of camptothecin-encapsulated poly(lactic-International journal of nanomedicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zongmin ZhaoDepartment of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, USA.
Yun HuDepartment of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, USA.
Theresa HarmonMinneapolis Medical Research Foundation, Minneapolis, MN, USA.
Paul R PentelMinneapolis Medical Research Foundation, Minneapolis, MN, USA.
Marion EhrichDepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, USA.
Chenming ZhangDepartment of Biological Systems Engineering, Virginia Tech, Blacksburg, VA, USA. Electronic address: chzhang2@vt.edu.

Funding

Novel Nanovaccines Against Nicotine AddictionU01DA036850 · NIDA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ZHANG, CHENMING M · 2014 to 2016
$2.3M
NIDA NIH HHS U01 DA036850
6 · The paper itself

Abstract

A series of hybrid nanoparticle-based nicotine nanovaccines (NanoNicVac) were engineered in this work by conjugating potent carrier protein candidates (Keyhole limpet hemocyanin (KLH) multimer, KLH subunit, cross-reactive material 197 (CRM

Indexed as

Adjuvants, ImmunologicAnimalsBacterial ProteinsBrainFemaleHemocyaninsImmunotherapyMiceMice, Inbred BALB CNanoparticlesNicotineTetanus ToxoidTobacco Use DisorderVaccines, SyntheticAdjuvants, ImmunologicBacterial ProteinsCRM197 (non-toxic variant of diphtheria toxin)Hemocyaninskeyhole-limpet hemocyaninNicotineTetanus ToxoidVaccines, SyntheticAnti-nicotine antibodyCarrier proteinHybrid nanoparticleNicotine addictionNicotine vaccine

Identifiers

PMID29719216
PMCPMC7262794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.