Evidence map›Paper›PMID 29719170›Full record

ArticleAmerican journal of physiology. Cell physiology2018

VEGF-A selectively inhibits FLT1 ectodomain shedding independent of receptor activation and receptor endocytosis.

Nandita S Raikwar, Masabumi Shibuya, Christie P Thomas

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Nandita S RaikwarDepartment of Internal Medicine, University of Iowa Carver College of Medicine , Iowa City, Iowa.
Masabumi ShibuyaInstitute of Physiology and Medicine, Jobu University, Takasaki, Gunma, Japan.
Christie P ThomasDepartment of Internal Medicine, University of Iowa Carver College of Medicine , Iowa City, Iowa.
University of Iowa · USJobu University · JP

Funding

Expression of sFlt1 and its function in the glomerular endotheliumR01DK090053 · NIDDK · UNIVERSITY OF IOWA · PI THOMAS, CHRISTIE P. · 2010 to 2014
$1.6M
NIDDK NIH HHS R01 DK090053
6 · The paper itself

Abstract

Ectodomain shedding and regulated intracellular proteolysis can determine the fate or function of cell surface proteins. Fms-related tyrosine kinase (FLT) or VEGF receptor 1 is a high-affinity cell surface VEGF-A receptor tyrosine kinase that is constitutively cleaved to release an NH

Indexed as

AnimalsCell LineChlorocebus aethiopsCOS CellsEndocytosisEndosomesHEK293 CellsHumansHuman Umbilical Vein Endothelial CellsMembrane ProteinsProteolysisReceptor Protein-Tyrosine KinasesReceptors, Cell SurfaceVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2FLT1 protein, humanMembrane ProteinsReceptor Protein-Tyrosine KinasesReceptors, Cell SurfaceVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2VEGFA protein, humanligand-mediated endocytosisproteolytic cleavagereceptor tyrosine kinase

Identifiers

PMID29719170
PMCPMC6139503
OpenAlexW2802056201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.