ReviewMedicine2018
Orofacial signs and dental abnormalities in patients with Mulvihill-Smith syndrome: A literature review on this rare progeroid pathology.
Review in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- sc-MULTI-omics approach in nano-rare diseases: understanding the pathophysiological mechanism of Mulvihill-Smith Syndrome.Functional & integrative genomics · 2025Article
- An improved diagnostic method for taurodontism and a comparative study on its effectiveness evaluation.PloS one · 2024Article
- Oral microbiota in human health and disease: A perspective.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Clinical Comparison of Diode Laser Assisted "v-Shape Frenectomy" and Conventional Surgical Method as Treatment of Ankyloglossia.Healthcare (Basel, Switzerland) · 2022Article
- Taurodontism in dental genetics.BDJ open · 2021Article
- Quality of Life of Patients with Mandibular Third Molars and Mild Pericoronitis. A Comparison between Two Different Treatments: Extraction or Periodontal Approach.Antibiotics (Basel, Switzerland) · 2020Article
- The Effectiveness of Chlorhexidine and Air Polishing System in the Treatment ofAntibiotics (Basel, Switzerland) · 2020Article
- Reasons for Tooth Extractions and Related Risk Factors in Adult Patients: A Cohort Study.International journal of environmental research and public health · 2020Article
- Severe Hyponatremia Triggered by Immune Checkpoint Inhibitor Therapy in a Patient With Mulvihill-Smith Syndrome.AACE clinical case reportsArticle
- Animal metaphors in oral pathology-A review.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMulvihill-Smith syndrome is a rare sporadic condition that was first recognized in 1975. A total of 11 cases have been described in the literature. The aim of this study was to describe the orofacial signs and dental anomalies, their frequency, and the relationship between Mulvihill-Smith syndrome and other progeroid syndromes via a review of the literature.
methodsA systematic PubMed search was performed to retrieve articles published between 1975 and the present day that described patients affected by Mulvihill-Smith syndrome. The search identified 14 articles, and data on 11 patients were extracted from the selected articles.
resultsA total of 7 patients (63.6%) affected by Mulvihill-Smith syndrome were described as having a typical "bird" face. Dental abnormalities, including irregular shape, enamel defects, hypodontia, and taurodontism, were described in 6 patients (54.5%). All patients (100%) had multiple pigmented nevi on the face and a lack or thinning of subcutaneous tissue around the neck and face. Three patients with Mulvihill-Smith syndrome exhibited early onset of tumors of the gastrointestinal tract, including the tongue.
conclusionMulvihill-Smith syndrome is a clinically complex disease that may be caused by a single gene mutation. Numerous different tissues of the body are affected. This analysis of the orofacial signs may help clinicians to diagnose this rare pathology.
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