ArticleMedicine2018
Comorbid risks of psychological disorders and gastroesophageal reflux disorder using the national health insurance service-National Sample Cohort: A STROBE-compliant article.
Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Mendelian randomization study of gastroesophageal reflux disease and major depression.PloS one · 2023Pooled it
- Healthcare burden of treated gastroesophageal reflux disease among U.S. adults, 2018-2023: a pooled cross-sectional analysis of the medical expenditure panel survey.Frontiers in medicine · 2026Article
- Bidirectional Association between Gastroesophageal Reflux Disease and Bipolar Disorder: A Systematic Review and Meta-analysis of Longitudinal Studies.Middle East journal of digestive diseases · 2025Review
- Assessment of gastroesophageal reflux disease signs, symptoms, and food behaviors concerning mental health in Herat, Afghanistan: A descriptive study.Health science reports · 2024Article
- Analyzing the correlation between gastroesophageal reflux disease and anxiety and depression based on ordered logistic regression.Scientific reports · 2024Article
- Prevalence and associated factors of worry for cancer in patients with a Barrett's esophagus.Scientific reports · 2024Article
- Barrett Esophagus: Quality of life and factors associated with illness perception.United European gastroenterology journal · 2022Article
- Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis.Journal of neurogastroenterology and motility · 2022Review
- Comparative Efficacy of Antidepressants for Symptoms Remission of Gastroesophageal Reflux: A Bayesian Network Meta-analysis of Randomized Controlled Trials.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Review
- Heartburn Center Set-Up in a Community Setting: Engineering and Execution.Frontiers in medicine · 2021Article
- The role of body mass index in determining clinical and quality of life outcomes after laparoscopic anti-reflux surgery.Surgical endoscopy · 2020Article
- Hearing impairment and the risk of neurodegenerative dementia: A longitudinal follow-up study using a national sample cohort.Scientific reports · 2018Article
- Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was performed to examine the comorbidity risks between psychological disorders, such as depression, and gastroesophageal reflux disease (GERD) using nationally representative data from a National Sample Cohort of the National Health Insurance Service in Korea.The National Health Insurance Service-National Sample Cohort (NHIS-NSC) database from 2010 to 2012 was used in this study. GERD patients were defined as those diagnosed with specific tests, with screened medication, and without any other gastrointestinal diseases. Propensity score matching for age, sex, and economic status was applied to form a control cohort. Incidence rate, relative risks, Cox proportional-hazards modeling, and Kaplan-Meier analysis were applied to examine the differences between the GERD and control cohorts with regard to the risk of subsequent psychological disorders.The results showed that patients in the GERD cohort (n = 9503) had significantly higher risks of psychological disorders than those without GERD (adjusted hazard ratio [HR] 1.25, 95% confidence interval [CI] 1.07-1.47, P = .006). Specifically, the risk of depressive disorder was significantly higher for patients in the GERD cohort than in the control cohort (adjusted HR 1.41, 95% CI 1.04-1.91, P = .027). Kaplan-Meier analysis showed that the estimated probability of psychological disorders was significantly higher in the GERD cohort compared with the control cohort (log-rank test, P = .007).This study suggested that GERD may be a risk factor for subsequent psychological disorders, specifically, depressive disorder. The results of this study in GERD patients compared with non-GERD patients in Korea suggested that psychological disorders and GERD may be inter-related.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.