Evidence map›Paper›PMID 29718808›Full record

ArticleJournal of neurophysiology2018

Differences in lumbar motor neuron pruning in an animal model of early onset spasticity.

Joline E Brandenburg, Heather M Gransee, Matthew J Fogarty, Gary C Sieck

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  3. Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026
    Review
  4. Article
  5. Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  6. Article
  7. Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Is baclofen the least worst option for spasticity management in children?Journal of pediatric rehabilitation medicine · 2023
    Article
  10. Article
  11. Article
  12. Diaphragm muscle function in a mouse model of early-onset spasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Growth and survival characteristics ofAnimal models and experimental medicine · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Joline E BrandenburgDepartment of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine , Rochester, Minnesota.ORCID 0000-0002-7932-9225
Heather M GranseeDepartment of Anesthesiology, Mayo Clinic College of Medicine , Rochester, Minnesota.
Matthew J FogartyDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine , Rochester, Minnesota.
Gary C SieckDepartment of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine , Rochester, Minnesota.
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Recovery of Respiratory Function After Spinal Cord InjuryR01HL096750 · NHLBI · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2010 to 2017
$4.9M
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS R01 HL096750NIA NIH HHS R01 AG044615
6 · The paper itself

Abstract

Motor neuron (MN) development in early onset spasticity is poorly understood. For example, spastic cerebral palsy (sCP), the most common motor disability of childhood, is poorly predicted by brain imaging, yet research remains focused on the brain. By contrast, MNs, via the motor unit and neurotransmitter signaling, are the target of most therapeutic spasticity treatments and are the final common output of motor control. MN development in sCP is a critical knowledge gap, because the late embryonic and postnatal periods are not only when the supposed brain injury occurs but also are critical times for spinal cord neuromotor development. Using an animal model of early onset spasticity [ spa mouse (B6.Cg- Glrb

Indexed as

Neuronal PlasticityAnimalsCerebral PalsyDendritesDisease Models, AnimalFemaleLumbosacral RegionMaleMice, KnockoutMotor NeuronsMuscle, SkeletalReceptors, GlycineSpinal CordSynaptic TransmissionReceptors, Glycineglycine receptormotor neuronspasticityspinal cord

Identifiers

PMID29718808
PMCPMC6139463
OpenAlexW2800127878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.