Evidence map›Paper›PMID 29718725›Full record

ArticleDrug delivery2018

Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors.

Chia-Yu Su, Michael Chen, Ling-Chun Chen, Yuan-Soon Ho, Hsiu-O Ho, Shyr-Yi Lin, Kuo-Hsiang Chuang, Ming-Thau Sheu

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chia-Yu Sua School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan, ROC.
Michael Chenb Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine , Taipei Medical University , Taipei , Taiwan, ROC.
Ling-Chun Chenc Department of Biotechnology and Pharmaceutical Technology , Yuanpei University of Medical Technology , Hsinchu , Taiwan, ROC.
Yuan-Soon Hod Graduate Institute of Medical Sciences, College of Medical Science and Technology , Taipei Medical University , Taipei , Taiwan, ROC.
Hsiu-O Hoa School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan, ROC.
Shyr-Yi Line Department of Primary Care Medicine , Taipei Medical University Hospital , Taipei , Taiwan, ROC.
Kuo-Hsiang Chuangb Ph.D. Program in Clinical Drug Development of Chinese Herbal Medicine , Taipei Medical University , Taipei , Taiwan, ROC.
Ming-Thau Sheua School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan, ROC.
Taipei Medical University · TWTaipei Medical University Hospital · TWYuanpei University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (L

Indexed as

AnimalsAntibodies, BispecificAntineoplastic AgentsCell Line, TumorDocetaxelDrug CarriersDrug Delivery SystemsErb-b2 Receptor Tyrosine KinasesFemaleHumansLecithinsMaleMCF-7 CellsMice, NudeNanoparticlesPhosphatidylethanolaminesAntibodies, BispecificAntineoplastic AgentsDocetaxelDrug CarriersERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesLecithinsPhosphatidylethanolaminespolyethylene glycol-distearoylphosphatidylethanolaminePolyethylene GlycolsTaxoidsactive targetingBispecific antibodychemotherapeuticsdocetaxelmPEGylated nanocarriers

Identifiers

PMID29718725
PMCPMC6058516
OpenAlexW2802105036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.