ArticleBrain : a journal of neurology2018
Ion channels in EEG: isolating channel dysfunction in NMDA receptor antibody encephalitis.
Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 85 citations in OpenAlex.
- Magnetoencephalographic Correlates of Suicidal Ideation in Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Trial
- Transcranial direct current stimulation over the sensory-motor regions inhibits gamma synchrony.Human brain mapping · 2019Trial
- Sleep deprivation impairs ventral hippocampus-medial prefrontal connectivity and task learning in rats.iScience · 2026Article
- Alzheimer's disease and memantine effects on NMDA-receptor blockade: non-invasive in vivo insights from magnetoencephalography.Molecular psychiatry · 2026Article
- Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus.Epilepsia · 2025Article
- Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography.Human brain mapping · 2025Article
- [A study on the effects of learning on the properties of rats hippocampal-prefrontal connections in a memory task].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations.World journal of radiology · 2024Review
- Predicting treatment response to ketamine in treatment-resistant depression using auditory mismatch negativity: Study protocol.PloS one · 2024Article
- Linking fast and slow: The case for generative models.Network neuroscience (Cambridge, Mass.) · 2024Review
- NORSE/FIRES: how can we advance our understanding of this devastating condition?Frontiers in neurology · 2024Review
- The micro and macro interactions in acute autoimmune encephalitis: a study of resting-state EEG.Frontiers in neurology · 2023Article
- GABAInternational journal of molecular sciences · 2022Article
- Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia.Biological psychiatry · 2022Article
- Cerebral Metabolic Network in Patients With Anti-Frontiers in neuroscience · 2022Article
- Computational approaches to treatment response prediction in major depression using brain activity and behavioral data: A systematic review.Network neuroscience (Cambridge, Mass.) · 2022Article
- Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures.The Journal of experimental medicine · 2021Article
- Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis.Communications biology · 2021Article
- In Vivo Assay of Cortical Microcircuitry in Frontotemporal Dementia: A Platform for Experimental Medicine Studies.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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8 authors at 5 institutions in 3 countries.
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Abstract
See Roberts and Breakspear (doi:10.1093/brain/awy136) for a scientific commentary on this article.Neurological and psychiatric practice frequently lack diagnostic probes that can assess mechanisms of neuronal communication non-invasively in humans. In N-methyl-d-aspartate (NMDA) receptor antibody encephalitis, functional molecular assays are particularly important given the presence of NMDA antibodies in healthy populations, the multifarious symptomology and the lack of radiological signs. Recent advances in biophysical modelling techniques suggest that inferring cellular-level properties of neural circuits from macroscopic measures of brain activity is possible. Here, we estimated receptor function from EEG in patients with NMDA receptor antibody encephalitis (n = 29) as well as from encephalopathic and neurological patient controls (n = 36). We show that the autoimmune patients exhibit distinct fronto-parietal network changes from which ion channel estimates can be obtained using a microcircuit model. Specifically, a dynamic causal model of EEG data applied to spontaneous brain responses identifies a selective deficit in signalling at NMDA receptors in patients with NMDA receptor antibody encephalitis but not at other ionotropic receptors. Moreover, though these changes are observed across brain regions, these effects predominate at the NMDA receptors of excitatory neurons rather than at inhibitory interneurons. Given that EEG is a ubiquitously available clinical method, our findings suggest a unique re-purposing of EEG data as an assay of brain network dysfunction at the molecular level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.