Evidence map›Paper›PMID 29717993›Full record

ArticleActa crystallographica. Section F, Structural biology communications2018

Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1.

Michael S Little, Matthew R Redinbo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The Impact ofAnimals : an open access journal from MDPI · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael S LittleDepartment of Chemistry, University of North Carolina, 4350 Genome Sciences Building, Chapel Hill, NC 27599-3290, USA.
Matthew R RedinboDepartment of Chemistry, University of North Carolina, 4350 Genome Sciences Building, Chapel Hill, NC 27599-3290, USA.
Human Genome Sciences (United States) · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 Å resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel.

Indexed as

Amino Acid SequenceAnimalsCrystallography, X-RayGlycoproteinsImmunity, InnateMicePermeabilityPhosphoproteinsProtein Structure, SecondaryProtein Structure, TertiaryBpifa1 protein, mouseGlycoproteinsPhosphoproteinsantimicrobial proteinsbacterial permeability-increasing family member A1biological chemistryBPIFA1innate immunity proteinslung biologyMus musculusprotein surfactantspulmonary proteinsstructural biologysurfactant proteins

Identifiers

PMID29717993
PMCPMC5931138
OpenAlexW2799965259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.