ArticleeLife2018
5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Ventral hippocampus neurons encode meal-related memory.Nature communications · 2025Article
- Exploring stress hormone effects on memory specificity and strength in mice using the dual-event inhibitory avoidance task.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Transcriptomic mapping of the 5-HT receptor landscape.Patterns (New York, N.Y.) · 2024Article
- Retrieval of contextual memory can be predicted by CA3 remapping and is differentially influenced by NMDAR activity in rat hippocampus subregions.PLoS biology · 2024Article
- Effects of sex and pro-inflammatory cytokines on context discrimination memory.Behavioural brain research · 2023Article
- Psychedelic-Induced Serotonin 2A Receptor Downregulation Does Not Predict Swim Stress Coping in Mice.International journal of molecular sciences · 2022Article
- Sex-specific effects of psychedelics on prepulse inhibition of startle in 129S6/SvEv mice.Psychopharmacology · 2022Article
- Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.Molecular psychiatry · 2022Article
- Pivotal mental states.Journal of psychopharmacology (Oxford, England) · 2021Review
- Recognition memory reconsolidation requires hippocampal Zif268.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recognition task, we examined the effect of medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval in reconsolidation of competing objects memories. We found that mPFC 5-HT2aR controls retrieval and reconsolidation of object memories in the perirhinal cortex (PRH), but not in the dorsal hippocampus in rats. Also, reconsolidation of objects memories in PRH required a functional interaction between the ventral hippocampus and the mPFC. Our results indicate that in the presence of conflicting information at retrieval, mPFC 5-HT2aR may facilitate top-down context-guided control over PRH to control the behavioral response and object memory reconsolidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.