Evidence map›Paper›PMID 29717936›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Different effects of global osteopontin and macrophage osteopontin in glomerular injury.

Jessica Trostel, Luan D Truong, Carlos Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Masanari Kuwabara, Rachel McMahan, Ana Andres-Hernando, Yuka Sato, Thomas Jensen and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in GN.Journal of the American Society of Nephrology : JASN · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Osteopontin: The Molecular Bridge between Fat and Cardiac-Renal Disorders.International journal of molecular sciences · 2020
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jessica TrostelDepartment of Medicine, Division of Renal Diseases and Hypertension.
Luan D TruongDepartment of Pathology, Baylor College of Medicine, and Department of Pathology, The Methodist Hospital , Houston, Texas.
Carlos Roncal-JimenezDepartment of Medicine, Division of Renal Diseases and Hypertension.
Makoto MiyazakiDepartment of Medicine, Division of Renal Diseases and Hypertension.
Shinobu Miyazaki-AnzaiDepartment of Medicine, Division of Renal Diseases and Hypertension.
Masanari KuwabaraDepartment of Medicine, Division of Renal Diseases and Hypertension.
Rachel McMahanDivision of Gastroenterology University of Colorado Denver, Aurora, Colorado.
Ana Andres-HernandoDepartment of Medicine, Division of Renal Diseases and Hypertension.
Yuka SatoDepartment of Medicine, Division of Renal Diseases and Hypertension.
Thomas JensenDepartment of Medicine, Division of Renal Diseases and Hypertension.
Miguel A LanaspaDepartment of Medicine, Division of Renal Diseases and Hypertension.
Richard J JohnsonDepartment of Medicine, Division of Renal Diseases and Hypertension.
Gabriela E GarciaDepartment of Medicine, Division of Renal Diseases and Hypertension.
Hypertension Institute · USBaylor College of Medicine · USUniversity of Colorado Denver · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
The role of MLKL in the regulation of vascular calcification in CKDR01HL132318 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAZAKI, MAKOTO · 2016 to 2025
$3.8M
Molecular Pathogenesis of Chronic Kidney Disease-Dependent Vascular CalcificationR01DK096030 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MIYAZAKI, MAKOTO · 2013 to 2017
$2.2M
The contributory role of microbial metabolite in the pathogenesis of CKD-dependent vascular calcificationR01HL133545 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAZAKI, MAKOTO · 2018 to 2021
$1.9M
The Role of Stearate in The Regulation of Vascular Calcification in Chronic Kidney DiseaseR01HL117062 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAZAKI, MAKOTO · 2013 to 2016
$1.5M
Reduction of kidney progressive fibrosis by A2A adenosine receptor activation: PR01DK082509 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GARCIA, GABRIELA E · 2011 to 2015
$1.3M
NHLBI NIH HHS R01 HL117062NHLBI NIH HHS R01 HL132318NHLBI NIH HHS R01 HL133545NIDDK NIH HHS R01 DK082509NIDDK NIH HHS R01 DK096030
6 · The paper itself

Abstract

Osteopontin (OPN) is a pro-and anti-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritis and in the progression of kidney injury. Importantly, OPN is highly induced in nephritic kidneys. To characterize further the role of OPN in kidney injury we used OPN

Indexed as

AnimalsDisease Models, AnimalGlomerulonephritisInflammationKidney GlomerulusMacrophagesMaleMice, KnockoutOsteopontinUrinary TractOsteopontinfibrosisglomerulonephritisinflammationosteopontinoxidative stress

Identifiers

PMID29717936
PMCPMC6230752
OpenAlexW2802591474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.