ArticleThe journal of nutrition, health & aging2018
Selenium Concentrations and Mortality among Community-Dwelling Older Adults: Results from IlSIRENTE Study.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.Redox biology · 2025Pooled it
- Trial
- Article
- Micronutrient Supplementation in Frailty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Healthcare (Basel, Switzerland) · 2025Review
- Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults.Nutrition & diabetes · 2025Article
- Selenium intake is associated with gait speed in very old adults.Frontiers in aging · 2025Article
- Effects of molecular interactions between the exposome and oxylipin metabolism on healthspan.Frontiers in physiology · 2025Review
- Influence of smoking status on the relationship between serum selenium and cause-specific mortality in US adults.Scientific reports · 2024Article
- Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study.The British journal of nutrition · 2024Article
- Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.European journal of epidemiology · 2024Article
- Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults.Nutrients · 2023Article
- Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.Molecules (Basel, Switzerland) · 2023Review
- Can We Slow Down Biological Age Progression? Study Protocol for the proBNPage Reduction (PBAR) Randomized, Double-Blind, Placebo-Controlled Trial (Effects of 4 "Anti-Aging" Food Supplements in Healthy Older Adults).Clinical interventions in aging · 2023Article
- Scientific opinion on the tolerable upper intake level for selenium.EFSA journal. European Food Safety Authority · 2023Article
- Severe Acquired Brain Injury: Prognostic Factors of Discharge Outcome in Older Adults.Brain sciences · 2022Article
- Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19.Clinics in geriatric medicine · 2022Review
- NaPharmaceuticals (Basel, Switzerland) · 2022Review
- Screening Lung Diseases Using Cascaded Feature Generation and Selection Strategies.Healthcare (Basel, Switzerland) · 2022Article
- Whole-Body Vibration Associated with Strength Training on the Lower-Limb Blood Flow and Mobility in Older Adults with Type 2 Diabetes: A Study Protocol for a Randomized Controlled Trial.Diagnostics (Basel, Switzerland) · 2022Article
- Frailty Network in an Acute Care Setting: The New Perspective for Frail Older People.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.
objectivesto investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. DESIGN AND
settingData are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.
resultsA total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).
conclusionsLow serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
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