Evidence map›Paper›PMID 29717465›Full record

ReviewScience and engineering ethics2019

Animal Models in Forensic Science Research: Justified Use or Ethical Exploitation?

Calvin Gerald Mole, Marise Heyns

Abstract readReview
PubMed Publisher
In one paragraph

Review in Science and engineering ethics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The current state of forensic imaging - post mortem imaging.International journal of legal medicine · 2025
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Calvin Gerald MoleDivision of Forensic Medicine and Toxicology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, P.O. Box 13914, Mowbray, 7705, South Africa. calvin.mole@uct.ac.za.ORCID 0000-0001-8483-8190
Marise HeynsDivision of Forensic Medicine and Toxicology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, P.O. Box 13914, Mowbray, 7705, South Africa.ORCID 0000-0002-4567-9665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A moral dilemma exists in biomedical research relating to the use of animal or human tissue when conducting scientific research. In human ethics, researchers need to justify why the use of humans is necessary should suitable models exist. Conversely, in animal ethics, a researcher must justify why research cannot be carried out on suitable alternatives. In the case of medical procedures or therapeutics testing, the use of animal models is often justified. However, in forensic research, the justification may be less evident, particularly when research involves the infliction of trauma on living animals. To determine how the forensic science community is dealing with this dilemma, a review of literature within major forensic science journals was conducted. The frequency and trends of the use of animals in forensic science research was investigated for the period 1 January 2012-31 December 2016. The review revealed 204 original articles utilizing 5050 animals in various forms as analogues for human tissue. The most common specimens utilized were various species of rats (35.3%), pigs (29.3%), mice (17.7%), and rabbits (8.2%) although different specimens were favored in different study themes. The majority of studies (58%) were conducted on post-mortem specimens. It is, however, evident that more needs to be done to uphold the basic ethical principles of reduction, refinement and replacement in the use of animals for research purposes.

Indexed as

Ethics, ResearchModels, AnimalAnestheticsAnimal ExperimentationAnimalsAnimals, LaboratoryCattleDogsEuthanasia, AnimalForensic SciencesMicePostmortem ChangesRabbitsRatsResearch DesignSheepAnesthetics3R’sAnimal experimentationAnimal modelsForensic researchPost-mortem studies

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.