ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Determinants of Abnormal Pulmonary Vasodilatory Response With Exercise in HFpEF: Pulmonary Vascular-Left Atrial Axis Abnormalities.Comprehensive Physiology · 2026Article
- Increased [Basic research in cardiology · 2024Article
- Strategies for Imaging Metabolic Remodeling of the Heart in Obesity and Heart Failure.Current cardiology reports · 2022Review
- Development of a PET/MRI exercise stress test for determining cardiac glucose dependence in pulmonary arterial hypertension.Pulmonary circulation · 2022Article
- Novel Methodology for Measuring Regional Myocardial Efficiency.IEEE transactions on medical imaging · 2021Article
- Dynamic FDG PET Imaging to Probe for Cardiac Metabolic Remodeling in Adults Born Premature.Journal of clinical medicine · 2021Article
- Hybrid PET/MR imaging in myocardial inflammation post-myocardial infarction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Positron emission tomography/MRI for cardiac diseases assessment.The British journal of radiology · 2020Review
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Positron emission tomography, computed tomography and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Value of simultaneous assessment of cardiac functions by PET/MRI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCardiac metabolic changes in heart disease precede overt contractile dysfunction. However, metabolism and function are not typically assessed together in clinical practice. The purpose of this study was to develop a cardiac positron emission tomography/magnetic resonance (PET/MR) stress test to assess the dynamic relationship between contractile function and metabolism in a preclinical model.
methodsFollowing an overnight fast, healthy pigs (45-50 kg) were anesthetized and mechanically ventilated.
resultsHypoxic stress induced a significant increase in heart rate, cardiac output, left ventricular (LV) ejection fraction (EF), and peak torsion. There was a significant decline in arterial SpO
conclusionPET/MR with continuous FDG infusion captures dynamic changes in both cardiac metabolism and contractile function. This technique warrants evaluation in human cardiac disease for assessment of subtle functional and metabolic abnormalities.
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Registered trials
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