ArticleEJNMMI physics2018
Determination of gamma camera calibration factors for quantitation of therapeutic radioisotopes.
Article in EJNMMI physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 62 citations in OpenAlex.
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- Comprehensive SPECT/CT system characterization and calibration forEJNMMI physics · 2020Article
- FMTVDM-TFMJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Positional dependence of activity determination in single photon emission computed tomography.Nuclear medicine communications · 2019Article
- Implementation of patient dosimetry in the clinical practice after targeted radiotherapy using [EJNMMI research · 2018Article
- Does Single Computed Tomography Attenuation Correction able to Surrogate Serial Computed Tomography Attenuation Correction in Single-Photon Emission Computed Therapy Imaging for Peptide Receptor Radionuclide Therapy Dosimetry Result?Journal of medical physicsArticle
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCamera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom geometries have been proposed for the determination of the camera calibration factor (CF). However, there is no consensus on which approach is the best. The aim of this study is to evaluate all these calibration methods, compare their performance, and propose a practical and accurate calibration method for SPECT quantitation of therapeutic radioisotopes. Twenty-one phantom experiments (Siemens Symbia SPECT/CT) and 12 Monte Carlo simulations (GATE v6.1) using three therapy isotopes (
resultsFor phantom experiments, CF obtained from PS and HS + WB agreed to within 6% (below 3% if experiments performed on the same day are considered). However, CF from HS + CB exceeded those from PS by 4-12%. Similar trend was found in simulation studies. Analysis of CFs from primary photons helped us to understand this discrepancy. It was due to underestimation of scatter by the TEW method, further enhanced by attenuation correction. This effect becomes less important when the source is distributed over the entire phantom volume (HS + WB and HC).
conclusionsCamera CF could be determined using planar scans of a point source, provided that the scatter and background contributions are removed, for example using the clinically available TEW method. This approach is simple and yet provides CF with sufficient accuracy (~ 5%) to be used in clinics for radiotracer quantification.
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