ArticleAnnals of intensive care2018
Iron metabolism in critically ill patients developing anemia of inflammation: a case control study.
Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Anemia of Critical Illness: A Concise Definitive Review in Critical Care.Critical care medicine · 2026Review
- Targeting ferroptosis in sepsis-induced cardiomyopathy: mechanisms and therapeutic potential of traditional Chinese Medicine.Frontiers in pharmacology · 2026Review
- Surgery and Acute Stress Decrease NRF2 mRNA Expression and Promote Iron Metabolism Alteration, Oxidative Stress, and Inflammatory Gene Expression in the Liver of Prehypertensive Rats.Physiological research · 2025Article
- Erythroferrone-Driven Regulation of Hepcidin and Iron Levels in Polytransfused Sickle Cell Anaemia Patients: A Prospective Study.BioMed research international · 2025Article
- Decrease in Hemoglobin Levels during Acute Attacks in Patients with Idiopathic Recurrent Pericarditis: A Model of Anemia in Acute Disease.Journal of clinical medicine · 2024Article
- Deciphering the iron enigma: Navigating the complexities of iron metabolism in critical illness.World journal of clinical cases · 2024Article
- Reduced Plasma Bone Morphogenetic Protein 6 Levels in Sepsis and Septic Shock Patients.Biomedicines · 2024Article
- Iron and ferritin effects on intensive care unit mortality: A meta-analysis.World journal of clinical cases · 2024Article
- Article
- Comparison of Standard and New Iron Status Biomarkers: A Prospective Cohort Study in Sepsis Patients.Healthcare (Basel, Switzerland) · 2023Article
- Iron Fortification and Supplementation: Fighting Anemia of Chronic Diseases or Fueling Obesity?Current developments in nutrition · 2021Article
- Article
- Role Of Intravenous Iron Over Nonsurgical Transfusions In Major Burns.Annals of burns and fire disasters · 2020Article
- Potential of Parameters of Iron Metabolism for the Diagnosis of Anemia of Inflammation in the Critically Ill.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2020Article
- Linkage of alterations in systemic iron homeostasis to patients' outcome in sepsis: a prospective study.Journal of intensive care · 2020Article
- Inflammatory anemia-associated parameters are related to 28-day mortality in patients with sepsis admitted to the ICU: a preliminary observational study.Annals of intensive care · 2019Article
- Iron deficiency and infection: another pathway to explore in critically ill patients?Intensive care medicine · 2018Article
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11 authors.
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Abstract
backgroundAnemia occurring as a result of inflammatory processes (anemia of inflammation, AI) has a high prevalence in critically ill patients. Knowledge on changes in iron metabolism during the course of AI is limited, hampering the development of strategies to counteract AI. This case control study aimed to investigate iron metabolism during the development of AI in critically ill patients.
methodsIron metabolism in 30 patients who developed AI during ICU stay was compared with 30 septic patients with a high Hb and 30 non-septic patients with a high Hb. Patients were matched on age and sex. Longitudinally collected plasma samples were analyzed for levels of parameters of iron metabolism. A linear mixed model was used to assess the predictive values of the parameters.
resultsIn patients with AI, levels of iron, transferrin and transferrin saturation showed an early decrease compared to controls with a high Hb, already prior to the development of anemia. Ferritin, hepcidin and IL-6 levels were increased in AI compared to controls. During AI development, erythroferrone decreased. Differences in iron metabolism between groups were not influenced by APACHE IV score.
conclusionsThe results show that in critically ill patients with AI, iron metabolism is already altered prior to the development of anemia. Levels of iron regulators in AI differ from septic controls with a high Hb, irrespective of disease severity. AI is characterized by high levels of hepcidin, ferritin and IL-6 and low levels of iron, transferrin and erythroferrone.
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