ArticleInternational journal of obesity (2005)2019
Biological and psychological mediators of the relationships between fat mass, fat-free mass and energy intake.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.The American journal of clinical nutrition · 2021Trial
- Specific metabolic rate and body weight regulation: racial and ethnic differences in mass-independent energy expenditure.Journal of endocrinological investigation · 2026Article
- From Diet to Oral and Periodontal Health: Exploring the Crucial Role of Nutrition-A Narrative Review.Nutrients · 2026Review
- Investigating the impact of body composition on the estimation of resting metabolic rate: new equations for adults aged ≥65 years developed using cross-sectional data.The American journal of clinical nutrition · 2025Article
- An adiposity force induces obesity in humans independently of a normal energy balance system-a thought experiment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Fat-free mass and resting metabolic rate are determinants of energy intake: implications for a theory of appetite control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Physiologic and Behavioral Correlates of Energy Intake in Emerging Adulthood: Cross-Sectional Analysis of the RIGHT Track Health Study.The Journal of nutrition · 2023Article
- Predictors of Post-Exercise Energy Intake in Adolescents Ranging in Weight Status from Overweight to Severe Obesity.Nutrients · 2022Article
- The Rise and Fall of Physiological Theories of the Control of Human Eating Behavior.Frontiers in nutrition · 2022Review
- Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study.BMC endocrine disorders · 2021Article
- Review
- The "drive to eat" hypothesis: energy expenditure and fat-free mass but not adiposity are associated with milk intake and energy intake in 12 week infants.The American journal of clinical nutrition · 2021Article
- Recharacterizing the Metabolic State of Energy Balance in Thrifty and Spendthrift Phenotypes.The Journal of clinical endocrinology and metabolism · 2020Article
- Brown adipose tissue volume and 18F-fluorodeoxyglucose uptake are not associated with energy intake in young human adults.The American journal of clinical nutrition · 2020Article
- Cognitive dietary restraint, disinhibition, and hunger are associated with 24-h energy expenditure.International journal of obesity (2005) · 2019Article
- Activity energy expenditure is an independent predictor of energy intake in humans.International journal of obesity (2005) · 2019Article
- Revisiting the Role of Exercise Countermeasure on the Regulation of Energy Balance During Space Flight.Frontiers in physiology · 2019Review
- Behaviour, energy balance, obesity and capitalism.European journal of clinical nutrition · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile recent studies in humans indicate that fat-free mass (FFM) is closely associated with energy intake (EI) when in energy balance, associations between fat mass (FM) and EI are inconsistent.
objectivesThe present study used a cross-sectional design to examine the indirect and direct effects of FFM, FM and resting metabolic rate (RMR) on EI in individuals at or close to energy balance.
methodsData for 242 individuals (114 males; 128 females; BMI = 25.7 ± 4.9 kg/m
resultsAfter adjusting for age, sex and study, linear regression and mediation analyses indicated that the effect of FFM on EI was mediated by RMR (P < 0.05). FM also independently predicted EI, with path analysis indicating a positive indirect association (mediated by RMR; P < 0.05), and a stronger direct negative association (P < 0.05). Leptin, insulin and insulin resistance failed to predict EI, but cognitive restraint was a determinant of EI and partially mediated the association between FM and EI (P < 0.05).
conclusionsWhile the association between FFM and EI was mediated by RMR, FM influenced EI via two separate and opposing pathways; an indirect 'excitatory' effect (again, mediated by RMR), and a stronger direct 'inhibitory' effect. Psychological factors such as cognitive restraint remain robust predictors of EI when considered alongside physiological determinants of EI, and indeed, have the potential to play a mediating role in the overall expression of EI.
Indexed as
Identifiers
29717270What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.