Evidence map›Paper›PMID 29717233›Full record

ReviewNature reviews. Immunology2018

Diverse developmental pathways of intestinal intraepithelial lymphocytes.

Benjamin D McDonald, Bana Jabri, Albert Bendelac

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. GPR15-guided CD8Nature · 2026
    Article
  7. Article
  8. GPR55 negatively regulates CD8Journal of molecular histology · 2026
    Article
  9. Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin D McDonaldCommittee on Immunology, University of Chicago, Chicago, IL, USA.
Bana JabriCommittee on Immunology, University of Chicago, Chicago, IL, USA.
Albert BendelacCommittee on Immunology, University of Chicago, Chicago, IL, USA. abendela@bsd.uchicago.edu.

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Innate and adaptive immunity in celiac diseaseR01DK067180 · NIDDK · UNIVERSITY OF CHICAGO · PI JABRI, BANA · 2005 to 2024
$8.5M
Transcriptional Regulation of Innate-Like T CellsR01AI038339 · NIAID · UNIVERSITY OF CHICAGO · PI ESTERHAZY, DARIA · 1996 to 2025
$7.6M
Transcriptional Regulation of Innate-Like T CellsR37AI038339 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2017 to 2023
$3.4M
Specificity of Intestinal Immunoglobulin AU01AI125250 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2016 to 2020
$2.5M
Preclinical Validation of Transglutaminase 2 as a Novel Target for Celiac DiseaseR01DK100619 · NIDDK · STANFORD UNIVERSITY · PI KHOSLA, CHAITAN · 2014 to 2018
$2.3M
NIAID NIH HHS R01 AI038339NIAID NIH HHS R37 AI038339NIAID NIH HHS U01 AI125250NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK067180NIDDK NIH HHS R01 DK100619
6 · The paper itself

Abstract

The intestinal epithelial barrier is patrolled by resident intraepithelial lymphocytes (IELs) that are involved in host defence against pathogens, wound repair and homeostatic interactions with the epithelium, microbiota and nutrients. Intestinal IELs are one of the largest populations of lymphocytes in the body and comprise several distinct subsets, the identity and lineage relationships of which have long remained elusive. Here, we review advances in unravelling the complexity of intestinal IEL populations, which comprise conventional αβ T cell receptor (TCRαβ)

Indexed as

AnimalsCeliac DiseaseCell DifferentiationCell LineageHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansImmunity, InnateInflammatory Bowel DiseasesIntestinal MucosaIntraepithelial LymphocytesLigandsMiceModels, ImmunologicalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaHistocompatibility Antigens Class IHistocompatibility Antigens Class IILigandsReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID29717233
PMCPMC6063796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.