ArticleScientific reports2018
Exploring intrinsically disordered proteins in Chlamydomonas reinhardtii.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Functions of Intrinsically Disordered Regions.Biology · 2025Review
- Thermoprotection by a cell membrane-localized metacaspase in a green alga.The Plant cell · 2024Article
- Prefoldin Subunits and Its Associate Partners: Conservations and Specificities in Plants.Plants (Basel, Switzerland) · 2024Review
- Protein intrinsically disordered region prediction by combining neural architecture search and multi-objective genetic algorithm.BMC biology · 2023Article
- A Trajectory of Discovery: Metabolic Regulation by the Conditionally Disordered Chloroplast Protein, CP12.Biomolecules · 2022Review
- Identification of Intrinsically Disordered Proteins and Regions in a Non-Model Insect SpeciesBiomolecules · 2022Article
- Association between dietary essential amino acids intake and metabolic biomarkers: influence of obesity among Chinese children and adolescents.Amino acids · 2021Article
- A new type of flexible CP12 protein in the marine diatom Thalassiosira pseudonana.Cell communication and signaling : CCS · 2021Article
- Towards an understanding of the role of intrinsic protein disorder on plant adaptation to environmental challenges.Cell stress & chaperones · 2021Article
- Evolutionary Study of Disorder in Protein Sequences.Biomolecules · 2020Article
- Evo-physio: on stress responses and the earliest land plants.Journal of experimental botany · 2020Article
- The pyrenoidal linker protein EPYC1 phase separates with hybrid Arabidopsis-Chlamydomonas Rubisco through interactions with the algal Rubisco small subunit.Journal of experimental botany · 2019Article
- Intrinsically Disordered Transactivation Domains Bind to TAZ1 Domain of CBP via Diverse Mechanisms.Biophysical journal · 2019Article
- In silico prediction of structural changes in human papillomavirus type 16 (HPV16) E6 oncoprotein and its variants.BMC molecular and cell biology · 2019Article
- Article
- Characterization of protein extracts from different types of human teeth and insight in biomineralization.Scientific reports · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The content of intrinsically disordered protein (IDP) is related to organism complexity, evolution, and regulation. In the Plantae, despite their high complexity, experimental investigation of IDP content is lacking. We identified by mass spectrometry 682 heat-resistant proteins from the green alga, Chlamydomonas reinhardtii. Using a phosphoproteome database, we found that 331 of these proteins are targets of phosphorylation. We analyzed the flexibility propensity of the heat-resistant proteins and their specific features as well as those of predicted IDPs from the same organism. Their mean percentage of disorder was about 20%. Most of the IDPs (~70%) were addressed to other compartments than mitochondrion and chloroplast. Their amino acid composition was biased compared to other classic IDPs. Their molecular functions were diverse; the predominant ones were nucleic acid binding and unfolded protein binding and the less abundant one was catalytic activity. The most represented proteins were ribosomal proteins, proteins associated to flagella, chaperones and histones. We also found CP12, the only experimental IDP from C. reinhardtii that is referenced in disordered protein database. This is the first experimental investigation of IDPs in C. reinhardtii that also combines in silico analysis.
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