ArticleScientific reports2018
Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 26 citations in OpenAlex.
- Sex-stratified polygenic risk scores for coronary artery disease incidence: Insights from a 20-year cohort study.BMC cardiovascular disorders · 2026Article
- Interplay between lifestyle factors and polygenic risk for incident coronary heart disease in a large multiethnic cohort.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Polygenic risk and incident coronary heart disease in a large multiethnic cohort.American journal of preventive cardiology · 2024Article
- In Search of Risk Factors: The Origin and Early Stages of Cardiovascular Epidemiology.Journal of cardiovascular development and disease · 2024Article
- Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African Americans.Research square · 2023Article
- Association of Joint Genetic and Social Environmental Risks With Incident Myocardial Infarction: Results From the Health and Retirement Study.Journal of the American Heart Association · 2023Article
- Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review.Journal of personalized medicine · 2023Review
- Article
- Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events.Circulation. Genomic and precision medicine · 2022Article
- Prognostic Modelling Studies of Coronary Heart Disease-A Systematic Review of Conventional and Genetic Risk Factor Studies.Journal of cardiovascular development and disease · 2022Review
- Genome-wide risk prediction of common diseases across ancestries in one million people.Cell genomics · 2022Article
- Predictive Ability of a Clinical-Genetic Risk Score for Venous Thromboembolism in Northern and Southern European Populations.TH open : companion journal to thrombosis and haemostasis · 2021Article
- Polygenic Risk Score: Clinically Useful Tool for Prediction of Cardiovascular Disease and Benefit from Lipid-Lowering Therapy?Cardiovascular drugs and therapy · 2021Review
- Genetics, its role in preventing the pandemic of coronary artery disease.Clinical cardiology · 2021Review
- A Multi-Marker Test for Analyzing Paired Genetic Data in Transplantation.Frontiers in genetics · 2021Review
- Genetic Risk Score for Coronary Heart Disease: Review.Journal of personalized medicine · 2020Review
- Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study.BMC medical genetics · 2020Article
- Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups.American journal of human genetics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. We used data from the GERA cohort (30-79 years old, 68 to 73% female). We utilized two GRSs with 12 and 51 SNPs, respectively, and the Framingham Risk Score (FRS) to estimate 10-year CHD risk. After a median 8.7 years of follow-up, 450 incident CHD events were documented (95 in AFR, 316 in LAT and 39 EA, respectively). In a model adjusting for principal components and risk factors, tertile 3 vs. tertile 1 of GRS_12 was associated with 1.86 (95% CI, 1.15-3.01), 1.52 (95% CI, 1.02-2.25) and 1.19 (95% CI, 0.77-1.83) increased hazard of CHD in AFR, LAT and EA, respectively. Inclusion of the GRSs in models containing the FRS did not increase the C-statistic but resulted in net overall reclassification of 10% of AFR, 7% LAT and EA and in reclassification of 13% of AFR and EA as well as 10% LAT in the intermediate FRS risk subset. Our results support the usefulness of incorporating genetic information into risk assessment for primary prevention among minority subjects in the U.S.
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