Evidence map›Paper›PMID 29717157›Full record

ArticleScientific reports2018

Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins.

Ann M Czyzewski, Lynda M McCaig, Michelle T Dohm, Lauren A Broering, Li-Juan Yao, Nathan J Brown, Maruti K Didwania, Jennifer S Lin, Jim F Lewis, Ruud Veldhuizen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

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  11. Solid-Phase Insertion ofMolecules (Basel, Switzerland) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ann M CzyzewskiDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.
Lynda M McCaigLawson Health Research Institute, Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada.
Michelle T DohmDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.
Lauren A BroeringDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.
Li-Juan YaoLawson Health Research Institute, Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada.
Nathan J BrownDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, USA.
Maruti K DidwaniaDepartment of Bioengineering, Stanford University, School of Medicine, Stanford, California, USA.
Jennifer S LinDepartment of Bioengineering, Stanford University, School of Medicine, Stanford, California, USA.
Jim F LewisLawson Health Research Institute, Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada.
Ruud VeldhuizenLawson Health Research Institute, Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada. rveldhui@uwo.ca.
Annelise E BarronDepartment of Bioengineering, Stanford University, School of Medicine, Stanford, California, USA. aebarron@stanford.edu.
Northwestern University · USStanford University · USWestern University · CALawson Health Research Institute · CA

Funding

Development of a Biomimetic Lung Surfactant ReplacementR01HL067984 · NHLBI · STANFORD UNIVERSITY · PI BARRON, ANNELISE EMILY · 2001 to 2010
$2.5M
NHLBI NIH HHS R01 HL067984
6 · The paper itself

Abstract

Acute lung injury (ALI) leads to progressive loss of breathing capacity and hypoxemia, as well as pulmonary surfactant dysfunction. ALI's pathogenesis and management are complex, and it is a significant cause of morbidity and mortality worldwide. Exogenous surfactant therapy, even for research purposes, is impractical for adults because of the high cost of current surfactant preparations. Prior in vitro work has shown that poly-N-substituted glycines (peptoids), in a biomimetic lipid mixture, emulate key biophysical activities of lung surfactant proteins B and C at the air-water interface. Here we report good in vivo efficacy of a peptoid-based surfactant, compared with extracted animal surfactant and a synthetic lipid formulation, in a rat model of lavage-induced ALI. Adult rats were subjected to whole-lung lavage followed by administration of surfactant formulations and monitoring of outcomes. Treatment with a surfactant protein C mimic formulation improved blood oxygenation, blood pH, shunt fraction, and peak inspiratory pressure to a greater degree than surfactant protein B mimic or combined formulations. All peptoid-enhanced treatment groups showed improved outcomes compared to synthetic lipids alone, and some formulations improved outcomes to a similar extent as animal-derived surfactant. Robust biophysical mimics of natural surfactant proteins may enable new medical research in ALI treatment.

Indexed as

Acute Lung InjuryAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalHydrogen-Ion ConcentrationMaximal Respiratory PressuresMolecular MimicryPeptoidsPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CPulmonary SurfactantsRatsRats, Sprague-DawleyTreatment OutcomePeptoidsPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CPulmonary Surfactants

Identifiers

PMID29717157
PMCPMC5931611
OpenAlexW2802039990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.