Evidence map›Paper›PMID 29717143›Full record

ArticleScientific reports2018

In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source.

Regine Gradl, Martin Dierolf, Benedikt Günther, Lorenz Hehn, Winfried Möller, David Kutschke, Lin Yang, Martin Donnelley, Rhiannon Murrie, Alexander Erl and 6 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Phase-contrast virtual chest radiography.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Regine GradlChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany. regine.gradl@tum.de.
Martin DierolfChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany.ORCID 0000-0001-5150-2949
Benedikt GüntherChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany.
Lorenz HehnChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany.
Winfried MöllerComprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377, München, Germany.ORCID 0000-0003-3072-1346
David KutschkeComprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377, München, Germany.
Lin YangComprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377, München, Germany.
Martin DonnelleyRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, Australia.
Rhiannon MurrieDepartment of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria, 3800, Australia.
Alexander ErlComprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377, München, Germany.
Tobias StoegerComprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377, München, Germany.ORCID 0000-0002-2790-0389
Bernhard GleichMunich School of BioEngineering, Technical University of Munich, Boltzmannstr. 11, 85748, Garching, Germany.
Klaus AchterholdChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany.ORCID 0000-0002-8724-1637
Otmar SchmidComprehensive Pneumology Center, Member of the German Center for Lung Research (DZL), Max-Lebsche-Platz 31, 81377, München, Germany.
Franz PfeifferChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany.
Kaye Susannah MorganChair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.

Identifiers

PMID29717143
PMCPMC5931574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.