ArticleNature communications2018
Substrate-bound outward-open structure of a Na
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 84 citations in OpenAlex.
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- Biosynthesis and import of the cytoprotective extremolytes ectoine and hydroxyectoine in the phylumFrontiers in microbiology · 2026Article
- Analytical Ultracentrifugation for Studying the Oligomeric State and Protein-Protein Interactions of Membrane Transporters.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The SLC-ome of membrane transport: From molecular discovery to physiology and clinical applications.Physiological reviews · 2025Review
- Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter.eLife · 2025Article
- Structural mechanisms of human sodium-coupled high-affinity choline transporter CHT1.Cell discovery · 2024Article
- Whole cell affinity for 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in the marine bacterium Candidatus Pelagibacter st. HTCC7211 explains marine dissolved HMP concentrations.Environmental microbiology reports · 2024Article
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- Characterisation of anhydro-sialic acid transporters from mucosa-associated bacteria.Microbiology (Reading, England) · 2024Article
- Structural and biophysical analysis of aeLife · 2024Article
- Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.Nature structural & molecular biology · 2024Article
- Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.Nature communications · 2023Article
- Collective Domain Motion Facilitates Water Transport in SGLT1.International journal of molecular sciences · 2023Article
- Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter.Nature communications · 2023Article
- Article
- Sialic Acid 4-N-Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter.ChemMedChem · 2022Article
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Authors and funding
21 authors at 11 institutions in 7 countries.
Weixiao Y WahlgrenDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden. Weixiao.YuanWahlgren@chem.gu.se.
Elin DunevallDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9781-200X
Rachel A NorthDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
Aviv PazDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1751, USA.
Mariafrancesca ScaliseDepartment DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci 4C, 87036, Arcavacata di Rende, Italy.
Paola BisignanoCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA.ORCID http://orcid.org/0000-0003-1789-762X
Johan Bengtsson-PalmeCentre for Antibiotic Resistance Research (CARe) at University of Gothenburg, Box 440, S-40530, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-6528-3158
Parveen GoyalDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
Elin ClaessonDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
Rhawnie Caing-CarlssonDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-8530-856X
Rebecka AnderssonDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
Konstantinos BeisDepartment of Life Sciences, Imperial College London, Exhibition Road, London, South Kensington, SW7 2AZ, UK.ORCID http://orcid.org/0000-0001-5727-4721
Ulf J NilssonCentre for Analysis and Synthesis, Department of Chemistry, Lund University, POB 124, S-22100, Lund, Sweden.ORCID http://orcid.org/0000-0001-5815-9522
Anne FarewellDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
Lorena PochiniDepartment DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci 4C, 87036, Arcavacata di Rende, Italy.
Cesare IndiveriDepartment DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P. Bucci 4C, 87036, Arcavacata di Rende, Italy.
Michael GrabeCardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, 94158, USA.
Renwick C J DobsonBiomolecular Interaction Centre and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, 8041, New Zealand.
Jeff AbramsonDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1751, USA.
S RamaswamyThe Institute for Stem Cell Biology and Regenerative Medicine (InStem), GKVK Post, Bangalore, 560065, Karnataka, India.
Rosmarie FriemannDepartment of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden. Rosmarie.Friemann@gu.se.ORCID http://orcid.org/0000-0002-5633-2894
University of Gothenburg · SEUniversity of Calabria · ITUniversity of California, Los Angeles · USUniversity of California, San Francisco · USDiamond Light Source · GBInstitute for Stem Cell Biology and Regenerative Medicine · INLund University · SERutherford Appleton Laboratory · GBStanford Medicine · USThe University of Melbourne · AUUniversity of Canterbury · NZ
Funding
Structures of sodium glucose transporters by cryo electron microscopyR01GM078844 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2006 to 2018
$5.3MComputational Studies of Sodium SymportersR01GM089740 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRABE, MICHAEL · 2011 to 2020
$2.8MFunctional and structural studies of unique pathogenic transporters involved in glycobiologyR01GM124783 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2017 to 2019
$1.3MStructure/Function Studies on the Ca2+: Cation Antiporter family of transportersR21HL093278 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2009 to 2010
$424kBiotechnology and Biological Sciences Research Council BB/H01778X/1DBT-Wellcome Trust India Alliance IA/E/16/1/502999Medical Research Council MR/N020103/1NHLBI NIH HHS R21 HL093278NIGMS NIH HHS R01 GM078844NIGMS NIH HHS R01 GM089740NIGMS NIH HHS R01 GM124783Wellcome Trust
Abstract
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus mirabilis. SiaT is a secondary active transporter of the sodium solute symporter (SSS) family, which use Na
Indexed as
Amino Acid SequenceN-Acetylneuraminic AcidOrganic Anion TransportersProtein FoldingSequence Homology, Amino AcidSodiumSubstrate SpecificitySymportersN-Acetylneuraminic AcidOrganic Anion Transporterssialic acid transport proteinsSodiumSymporters
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