Evidence map›Paper›PMID 29717114›Full record

ArticleNature communications2018

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.

Virginia Murillo-Garzón, Irantzu Gorroño-Etxebarria, Malin Åkerfelt, Mikael Christer Puustinen, Lea Sistonen, Matthias Nees, James Carton, Jonathan Waxman, Robert M Kypta

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
  2. Article
  3. Science advances · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Unleashing Wnts: Wnt Ligands Fuel Cancer Spread.Journal of cancer biology · 2025
    Article
  9. Frizzled receptors: gatekeepers of Wnt signaling in development and disease.Frontiers in cell and developmental biology · 2025
    Review
  10. Emerging roles and biomarker potential of WNT6 in human cancers.Cell communication and signaling : CCS · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. The Roles of Secreted Wnt Ligands in Cancer.International journal of molecular sciences · 2023
    Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Virginia Murillo-GarzónCenter for Cooperative Research in Biosciences, CIC bioGUNE, 48160, Derio, Spain.
Irantzu Gorroño-EtxebarriaCenter for Cooperative Research in Biosciences, CIC bioGUNE, 48160, Derio, Spain.
Malin ÅkerfeltInstitute of Biomedicine, University of Turku, FI-20520, Turku, Finland.
Mikael Christer PuustinenFaculty of Science and Engineering, Åbo Akademi University, FI-20014, Turku, Finland.
Lea SistonenFaculty of Science and Engineering, Åbo Akademi University, FI-20014, Turku, Finland.
Matthias NeesInstitute of Biomedicine, University of Turku, FI-20520, Turku, Finland.
James CartonInstitute of Biomedicine, University of Turku, FI-20520, Turku, Finland.
Jonathan WaxmanDepartment of Surgery and Cancer, Imperial College London, London, W12 0NN, UK.
Robert M KyptaCenter for Cooperative Research in Biosciences, CIC bioGUNE, 48160, Derio, Spain. rmkypta@gmail.com.ORCID http://orcid.org/0000-0002-2389-310X
CIC bioGUNE · ESUniversity of Turku · FIÅbo Akademi University · FIImperial College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD

Indexed as

Signal TransductionActivating Transcription Factor 2Cell Line, TumorEpithelial-Mesenchymal TransitionGene SilencingHumansMaleNeoplasm InvasivenessNeoplasm MetastasisProstatic NeoplasmsReceptors, Cell SurfaceReceptors, Transforming Growth Factor betaSmad ProteinsTransforming Growth Factor betaWnt ProteinsActivating Transcription Factor 2ATF2 protein, humanFzd8 protein, humanReceptors, Cell SurfaceReceptors, Transforming Growth Factor betaSmad ProteinsTransforming Growth Factor betaWnt11 protein, humanWnt Proteins

Identifiers

PMID29717114
PMCPMC5931552
OpenAlexW2800803762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.