ArticleNature communications2018
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c
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In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 365 papers.
0numbers the graph read from it
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365citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
365 citing papers in PubMed, 548 citations in OpenAlex.
- IgA2Cell reports. Medicine · 2025Trial
- Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report.Lupus science & medicine · 2025Trial
- Immune profiling of patients with extranodal natural killer/T cell lymphoma treated with daratumumab.Annals of hematology · 2024Trial
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity · 2026Article
- Disease modification in lupus nephritis: towards a pathophysiology-based treatment paradigm.Nature reviews. Nephrology · 2026Review
- Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis.Cardiovascular research · 2026Article
- The SLC15A4-TASL complex is essential for lupus development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis.Hepatology communications · 2026Article
- [Pathophysiological aspects of primary Sjögren's disease : From epithelial activation to systemic autoimmunity].Zeitschrift fur Rheumatologie · 2026Review
- Structure-function analysis of the FCRL5-IgG1 Fc complex reveals an unappreciated pathway for B cell modulation by Fc-attenuated IgG.Science advances · 2026Article
- Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq.Nature communications · 2026Article
- Age-Associated B Cells: Origins, Regulation, and Tissue-Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases.Immunological reviews · 2026Review
- The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments.Immunological reviews · 2026Review
- Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Rheumatoid Arthritis by Inducing Age-Associated B Cells Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- MechAInistic: A Reviewer-Supervised Multi-Agent LLM System for Auditable Mechanistic Drug-Hypothesis Generation.bioRxiv : the preprint server for biology · 2026Article
- Autoreactive B cells in systemic lupus erythematosus: insights from integrative multi-omics analyses.Inflammation and regeneration · 2026Review
- Human CD21Journal of human immunity · 2026Review
- C5 inhibition restores B cell homeostasis and humoral immunity in CHAPLE disease patients.Journal of human immunity · 2026Article
- Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE.Lupus science & medicine · 2026Article
- From Genes to Pathways: The Molecular Landscape of Systemic Lupus Erythematosus.International journal of molecular sciences · 2026Review
305 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 1 country.
Shu WangRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Jingya WangRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Varsha KumarRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Jodi L KarnellRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Brian NaimanRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Phillip S GrossRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.ORCID http://orcid.org/0000-0003-2642-6504
Saifur RahmanRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Kamelia ZerroukiRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Richard HannaRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Christopher MorehouseTranslational Medicine, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Nicholas HoloweckyjTranslational Medicine, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Hao LiuTranslational Medicine, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Autoimmunity Molecular Medicine Team
Zerai MannaThe Office of Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Raphaela Goldbach-ManskyNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Sarfaraz HasniThe Office of Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-4164-8837
Richard SiegelThe Office of Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Miguel SanjuanRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Katie StreicherTranslational Medicine, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Michael P CancroDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Roland KolbeckRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA.
Rachel EttingerRespiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD, 20878, USA. ettingerr@vielabio.com.ORCID http://orcid.org/0000-0003-3761-9571
National Institutes of Health · USUniversity of Pennsylvania · USAutoimmune Technologies (United States) · USBristol-Myers Squibb (United States) · USIntegrated BioTherapeutics (United States) · US
Funding
Clinical Support Services for the NIAMS Intramural Research ProgramZIDAR041180 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$119.2MPathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Stills-like Diseases, and other Undifferentiated Autoinflammatory DiseasesZIAAI001220 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2017 to 2025
$22.3MTNF-receptors and programmed cell death in regulation of autoimmunityZIAAR041133 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI SIEGEL, RICHARD M · 2009 to 2019
$9.3MMechanistic studies of BLyS-mediated modulation in HIV-1 Env-specific antibody responsesR01AI118691 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CANCRO, MICHAEL PAUL · 2015 to 2019
$3.4MNIAID NIH HHS R01 AI118691
Abstract
Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11c
Indexed as
AdultAgedAged, 80 and overB-LymphocytesB-Lymphocyte SubsetsCD11c AntigenCell DifferentiationCohort StudiesFemaleHumansInterleukin-21InterleukinsLupus Erythematosus, SystemicMaleMiddle AgedPlasma CellsCD11c AntigenInterleukin-21InterleukinsT-Box Domain Proteins
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.