Evidence map›Paper›PMID 29716954›Full record

ArticleDisease models & mechanisms2018

Nmnat mitigates sensory dysfunction in a

Jennifer M Brazill, Beverley Cruz, Yi Zhu, R Grace Zhai

Abstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. PDH Inhibition inBiomedicines · 2025
    Article
  6. Review
  7. Article
  8. Cellular Pathogenesis of Chemotherapy-Induced Peripheral Neuropathy: Insights FromFrontiers in pain research (Lausanne, Switzerland) · 2022
    Review
  9. Article
  10. Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Biology open · 2021
    Article
  12. Review
  13. Article
  14. Review
  15. PeripheralPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  16. Article
  17. Chemotherapy-Induced Peripheral Neuropathy and Changes in Cytoskeleton.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer M BrazillDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Beverley CruzDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Yi ZhuDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-1778-8880
R Grace ZhaiDepartment of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA gzhai@med.miami.edu.ORCID 0000-0002-0956-9784

Funding

Enhance Neuroprotection through post-transcriptional regulationsR56NS095893 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZHAI, RONG GRACE · 2017 to 2017
$384k
NINDS NIH HHS R56 NS095893
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is the major dose-limiting side effect of many commonly used chemotherapeutic agents, including paclitaxel. Currently, there are no neuroprotective or effective symptomatic treatments for CIPN. Lack of understanding of the

Indexed as

AnimalsCell CountDendritesDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsFemaleLarvaMaleMicrotubulesNicotinamide-Nucleotide AdenylyltransferaseNociceptionPaclitaxelPeripheral Nervous System DiseasesSensory Receptor CellsDrosophila ProteinsNicotinamide-Nucleotide AdenylyltransferaseNmnat protein, DrosophilaPaclitaxelChemotherapyMicrotubulesNeuropathyNeuroprotectionNmnatPaclitaxel

Identifiers

PMID29716954
PMCPMC6031360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.