ArticleRadiation oncology (London, England)2018
Preexisting radiological interstitial lung abnormalities are a risk factor for severe radiation pneumonitis in patients with small-cell lung cancer after thoracic radiation therapy.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Clinical outcomes of interstitial lung abnormalities: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal environment.Radiation oncology (London, England) · 2022Trial
- Quantitative lung tissue functional analysis for pulmonary adverse event risk assessment prior to thoracic radiotherapy.Physics and imaging in radiation oncology · 2026Article
- CT-guided core needle biopsy of focal pulmonary lesions with coexisting interstitial lung abnormalities: a case-control study.European radiology · 2026Article
- Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases.Tuberculosis and respiratory diseases · 2025Article
- Prognostic impacts of interstitial lung abnormalities on outcomes following resection for lung cancer.BMJ open respiratory research · 2025Article
- A Comprehensive Review of Interstitial Lung Abnormalities.Respirology (Carlton, Vic.) · 2025Review
- Current perspectives on interstitial lung abnormalities.The Korean journal of internal medicine · 2025Review
- The impact of pre-existing interstitial lung disease on radiation and checkpoint inhibitor pneumonitis in lung cancer patients: a systematic review and meta-analysis.Therapeutic advances in medical oncology · 2025Article
- Efficacy and safety of thoracic radiotherapy combined with anti-angiogenic therapy and immunochemotherapy for advanced non-small cell lung cancer patients: a retrospective study.Frontiers in oncology · 2025Article
- Development of a predictive model for radiation pneumonitis based on plasma exosomal miR-200b-5p.Frontiers in oncology · 2025Article
- Construction and evaluation of a predictive model for radiation-induced lung injury in lung cancer: a meta-analysis.American journal of translational research · 2025Review
- First-line chemoimmunotherapy for patients with small-cell lung cancer and interstitial lung abnormality: CIP risk and prognostic analysis.Thoracic cancer · 2024Article
- Computed tomography patterns and clinical outcomes of radiation pneumonitis in non-small-cell lung cancer patients.Acta radiologica open · 2024Article
- Association between interstitial lung abnormality and mortality in patients with esophageal cancer.Japanese journal of radiology · 2024Article
- Deleterious impact of trivial to severe interstitial pneumonia and emphysema on mortality and acute exacerbation of interstitial pneumonia in patients with lung cancer: a retrospective cohort study.BMC pulmonary medicine · 2024Article
- Automated CT quantification of interstitial lung abnormality and interstitial lung disease according to the Fleischner Society in patients with resectable lung cancer: prognostic significance.European radiology · 2023Article
- Pre-Existing Interstitial Lung Abnormalities in Patients with Head and Neck Squamous Cell Carcinoma and Their Follow Up after Therapy.Diagnostics (Basel, Switzerland) · 2023Article
- Review
- Association between pre-treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis.Cancer immunology, immunotherapy : CII · 2023Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT). The present study aimed to evaluate the incidence and predictors of RP after TRT in patients with small-cell lung cancer (SCLC) with or without preexisting radiological ILAs.
methodsA total of 95 consecutive patients with SCLC between January 2015 and December 2015, who were treated with thoracic intensity-modulated radiation therapy at Shanghai Pulmonary Hospital,Tongji University School of Medicine, were analyzed. The diagnosis of ILAs was reviewed by two experienced thoracic radiologists based on the pretreatment high-resolution computed tomography imaging, such as honeycombing, subpleural reticular opacities, ground-glass opacity, and traction bronchiectasis. Univariate and multivariate analyses were used to assess the correlation of clinical factors, preexisting radiological ILAs, and dose-volume histogram-based dosimetric parameters with RP.
resultsFifteen (15.8%) patients had preexisting radiological ILAs. The incidence of ≥ grade 2 and 3 RP at 1 year was 27.1% and 12.7% in the entire cohort, respectively. Preexisting radiological ILAs were associated with an increased risk of ≥grade 2 RP (50.0% in ILAs + vs 23.3% in ILAs-, P = 0.017) and ≥ grade 3 RP (35.8% in ILAs + vs 8.9% in ILAs-, P = 0.005) at 1 year. Preexisting radiological ILAs and smoking history (≥40 pack-years of smoking) were significant predictors of ≥grade 3 RP in multivariate analysis (P = 0.023 and 0.012, respectively).
conclusionsPreexisting radiological ILAs and smoking history (≥40 pack-years of smoking) are associated with an increased risk of ≥grade 3 RP after TRT in patients with SCLC.
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