Evidence map›Paper›PMID 29716568›Full record

SynthesisBMC public health2018

MERS transmission and risk factors: a systematic review.

Ji-Eun Park, Soyoung Jung, Aeran Kim, Ji-Eun Park

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in BMC public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04420260 (Scheme of Primary Prevention of Infection by COVID-19, in Workers), which is not on this map. Cited by 156 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 18 pooled it
33.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04420260 nacompletednot on this mapstarted 2021, after this paper: background citation

Scheme of Primary Prevention of Infection by COVID-19, in Workers: Phase II Controlled Clinical Trial, to be Carried Out in Medellín-Antioquia

TypeinterventionalSponsorUnidad de Investigación Genética MolecularRan2021 to 2021Enrolled152ConditionsCOVIDArmsGroup A: oropharygeal spray and immunostimulant emulsion, Group D:Placebo oropharyngeal spray + Placebo taken PO
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 18 syntheses or guidelines pooled it, 305 citations in OpenAlex.

  1. The role of smoking in COVID-19 progression: a comprehensive meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
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  8. Cardiovascular Manifestations and Mechanisms in Patients with COVID-19.Trends in endocrinology and metabolism: TEM · 2020
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  10. Guideline
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  12. Smoking Is Associated With COVID-19 Progression: A Meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
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  18. The double burden of diabetes and global infection in low and middle-income countries.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019
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  19. Article
  20. Variable DPP4 expression in multiciliated cells of the human nasal epithelium as a determinant for MERS-CoV tropism.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ji-Eun ParkResearch Center for Korean Medicine Policy, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.ORCID 0000-0002-2932-5373
Soyoung JungClinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Aeran KimClinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Ji-Eun ParkHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. jepark@kiom.re.kr.
Korea Institute of Oriental Medicine · KR

Funding

National Research Council of Science and Technology CRC-16-01-KRICT
6 · The paper itself

Abstract

backgroundSince Middle East respiratory syndrome (MERS) infection was first reported in 2012, many studies have analysed its transmissibility and severity. However, the methodology and results of these studies have varied, and there has been no systematic review of MERS. This study reviews the characteristics and associated risk factors of MERS.

methodWe searched international (PubMed, ScienceDirect, Cochrane) and Korean databases (DBpia, KISS) for English- or Korean-language articles using the terms "MERS" and "Middle East respiratory syndrome". Only human studies with > 20 participants were analysed to exclude studies with low representation. Epidemiologic studies with information on transmissibility and severity of MERS as well as studies containing MERS risk factors were included.

resultA total of 59 studies were included. Most studies from Saudi Arabia reported higher mortality (22-69.2%) than those from South Korea (20.4%). While the R

conclusionThe transmissibility and severity of MERS differed by outbreak region and patient characteristics. Further studies assessing the risk of MERS should consider these factors.

Indexed as

Disease OutbreaksCoronavirus InfectionsHumansRepublic of KoreaRisk FactorsSaudi ArabiaInfectivityMERSMiddle East respiratory syndromeMortalitySeverity

Identifiers

PMID29716568
PMCPMC5930778
OpenAlexW2807702319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.