Evidence map›Paper›PMID 29716535›Full record

SynthesisBMC cardiovascular disorders2018

Predictive value of neutrophil to lymphocyte ratio in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention: a meta-analysis.

Sai Zhang, Jun Diao, Chunmei Qi, Jingjing Jin, Li Li, Xingjuan Gao, Lei Gong, Weiheng Wu

Open access · goldAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 2 syntheses or guidelines pooled it, 173 citations in OpenAlex.

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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sai ZhangDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jun DiaoDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Chunmei QiDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Jingjing JinDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Li LiDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xingjuan GaoDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Lei GongDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Weiheng WuDepartment of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. wwheng118@163.com.ORCID 0000-0002-3123-7807
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe neutrophil to lymphocyte ratio (NLR) is an indicator of systemic inflammation and a prognostic marker in patients with acute coronary syndrome (ACS). This study aims to investigate the value of NLR to predict the in-hospital and long-term prognosis in patients with ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) by meta-analysis.

methodThe studies related to the prognosis of NLR and STEMI patients published in the Pubmed, Embase, and Ovid databases before June 2017 were retrieved. The relevant data were extracted. Review Manager Version 5.3 was used for meta-analysis.

resultsA total of 14 studies of 10,245 patients with STEMI after PCI were included. A significant difference was observed for mortality (P < 0.001; relative risk (RR) 3.32; 95% confidence interval (CI) 2.45-4.49), hospital cardiac mortality(P < 0.001; RR 3.22; 95% CI 2.25-4.60), all mortality (P < 0.001; RR 3.23; 95% CI 2.28-4.57), major adverse cardiovascular events (MACE) (P < 0.001; RR 2.00; 95% CI 1.62-2.46), in-stent thrombosis (P < 0.001; RR 2.72 95% CI 1.66-4.44), nonfatal myocardial infarction(MI) (P < 0.001; RR 1.93; 95%CI 1.43-2.61), angina (P = 0.007; RR 1.67; 95%CI 1.15-2.41), advanced heart failure (AHF) (P < 0.001; RR 1.81; 95% CI 1.48-2.21), arrhythmia (P = 0.002; RR 1.38; 95% CI 1.13-1.69), no reflow (P < 0.001; RR 2.28; 95% CI 1.46-3.57), long-term all mortality (P < 0.001; RR 3.82; 95% CI 2.94-4.96), cardiac mortality (P = 0.004; RR 3.02; 95% CI 1.41-6.45), MACE (P < 0.001; RR 2.49; 95% CI 1.47-4.23), and nonfatal MI (P = 0.46; RR 1.32; 95% CI 0.63-2.75).

conclusionsMeta-analysis shows that NLR is a predictor of hospitalization and long-term prognosis in patients with STEMI after PCI, but requires further confirmation by large randomized clinical trials.

Indexed as

LymphocytesNeutrophilsPercutaneous Coronary InterventionAgedCause of DeathDisease ProgressionFemaleHospital MortalityHumansLymphocyte CountMaleMiddle AgedPredictive Value of TestsRecurrenceRisk FactorsST Elevation Myocardial InfarctionInflammationMortalityNeutrophil to lymphocyte ratioPercutaneous coronary interventionPrognosisST segment elevation myocardial infarction

Identifiers

PMID29716535
PMCPMC5930503
OpenAlexW2806777674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.