Evidence map›Paper›PMID 29716523›Full record

ArticleBMC neuroscience2018

Mice lacking galectin-3 (Lgals3) function have decreased home cage movement.

Tammy R Chaudoin, Stephen J Bonasera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tammy R ChaudoinDivision of Geriatrics, Department of Internal Medicine, University of Nebraska Medical Center, 3028 Durham Research Center II, Omaha, NE, 68198-5039, USA.
Stephen J BonaseraDivision of Geriatrics, Department of Internal Medicine, University of Nebraska Medical Center, 3028 Durham Research Center II, Omaha, NE, 68198-5039, USA. sbonasera@unmc.edu.
University of Nebraska Medical Center · US

Funding

Modifying age-related changes in mouse neuroinflammation & functional behaviorsR01AG031158 · NIA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BONASERA, STEPHEN J · 2009 to 2013
$2.9M
NIA NIH HHS R01 AG031158
6 · The paper itself

Abstract

backgroundGalectins are a large family of proteins evolved to recognize specific carbohydrate moieties. Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and immune recognition, we examined the home cage behavioral phenotype of mice lacking galectin-3 (Lgals3) function. Using a sophisticated monitoring apparatus capable of examining feeding, drinking, and movement at millisecond temporal and 0.5 cm spatial resolutions, we observed daily behavioral patterns from 10 wildtype male C57BL/6J and 10 Lgals3 constitutive knockout (Lgals3

resultsAt both ages, Lgals3

conclusionCarbohydrate recognition tasks performed by Lgals3 may be required for appropriate development of CNS structures involved in the generation and control of locomotor behavior.

Indexed as

AnimalsBehavior, AnimalCircadian RhythmGalectin 3LocomotionMice, Inbred C57BLMice, KnockoutRecognition, PsychologyGalectin 3Lgals3 protein, mouseCircadian rhythmGalectin-3Ingestive behaviorLgals3Locomotor behavior

Identifiers

PMID29716523
PMCPMC5930520
OpenAlexW2805616178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.