ArticleThe Journal of the Acoustical Society of America2018
Acoustic vaporization threshold of lipid-coated perfluoropentane droplets.
Article in The Journal of the Acoustical Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Phase-change perfluorocarbon nanodroplets enable spatiotemporal control of ultrasound and photoacoustic imaging and therapy.Biomedical engineering letters · 2026Review
- A two-stage transdermal drug delivery system comprising sono-phase-change transfersomes for non-invasive deep dermal delivery.Journal of nanobiotechnology · 2025Article
- The Role of Acoustic Parameters in Droplet Vaporization of Perfluoropentane Nanodroplets forACS applied materials & interfaces · 2025Article
- Optimising the manufacture of perfluorocarbon nanodroplets through varying sonication parameters.Ultrasonics sonochemistry · 2025Article
- Initial nucleation of nanodroplets in viscoelastic tissue driven by ultrasound: A theoretical simulation.Ultrasonics sonochemistry · 2025Article
- Acoustic droplet vaporization for on-demand modulation of microporosity in smart hydrogels.Acta biomaterialia · 2023Article
- Predicting initial nucleation events occurred in a metastable nanodroplet during acoustic droplet vaporization.Ultrasonics sonochemistry · 2021Article
- Numerical investigation of acoustic vaporization threshold of microdroplets.Ultrasonics sonochemistry · 2021Article
- Contrast-Enhanced Sonography with Biomimetic Lung Surfactant Nanodrops.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Echogenic Exosomes as ultrasound contrast agents.Nanoscale advances · 2020Article
- Acoustic Droplet Vaporization in Acoustically Responsive Scaffolds: Effects of Frequency of Excitation, Volume Fraction and Threshold Determination Method.Ultrasound in medicine & biology · 2019Article
- Impact of hydrostatic pressure on phase-change contrast agent activation by pulsed ultrasound.The Journal of the Acoustical Society of America · 2019Article
- Enhancement of HIFU ablation by sonosensitizer-loading liquid fluorocarbon nanoparticles with pre-targeting in a mouse model.Scientific reports · 2019Article
- Effects of droplet size and perfluorocarbon boiling point on the frequency dependence of acoustic vaporization threshold.The Journal of the Acoustical Society of America · 2019Article
- Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation andFrontiers in pharmacology · 2019Article
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3 authors.
Funding
Abstract
Phase shift droplets vaporizable by acoustic stimulation offer the advantages of producing microbubbles as contrast agents in situ as well as higher stability and the possibility of achieving smaller sizes. Here, the acoustic droplet vaporization (ADV) threshold of a suspension of droplets with a perfluoropentane (PFP) core (diameter 400-3000 nm) is acoustically measured as a function of the excitation frequency in a tubeless setup at room temperature. The changes in scattered responses-fundamental, sub-, and second harmonic-are investigated, a quantitative criterion is used to determine the ADV phenomenon, and findings are discussed. The average threshold obtained using three different scattered components increases with frequency-1.05 ± 0.28 MPa at 2.25 MHz, 1.89 ± 0.57 MPa at 5 MHz, and 2.34 ± 0.014 MPa at 10 MHz. The scattered response from vaporized droplets was also found to qualitatively match with that from an independently prepared lipid-coated microbubble suspension in magnitude as well as trends above the determined ADV threshold value.
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