ArticleImmunology1988
Opsonin-dependent and independent surface phagocytosis of S. aureus proceeds independently of complement and complement receptors.
Article in Immunology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
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- Unraveling the Interconnection Patterns Across Lung Microbiome, Respiratory Diseases, and COVID-19.Frontiers in cellular and infection microbiology · 2020Review
- A scavenging system against internal pathogens promoted by the circulating protein apoptosis inhibitor of macrophage (AIM).Seminars in immunopathology · 2018Review
- Phagocytosis and killing of Staphylococcus aureus by human neutrophils.Journal of innate immunity · 2014Article
- Melatonin and the phagocytic process of heterophils from the ring dove (Streptopelia risoria).Molecular and cellular biochemistry · 1997Article
- Group B streptococcus-induced nitric oxide production in murine macrophages is CR3 (CD11b/CD18) dependent.Infection and immunity · 1994Article
- Antibacterial properties of breast milk: requirements for surface phagocytosis and chemiluminescence.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1991Article
- Binding of Mycobacterium avium-Mycobacterium intracellulare to human leukocytes.Infection and immunity · 1990Article
- Phagocytic function and antibody-dependent cellular cytotoxicity of human neutrophils in the presence of N-formimidoyl thienamycin.Agents and actions · 1990Article
- Effects of chemotactic peptide f-Met-Leu-Phe (FMLP) on C3b receptor (CR1) expression and phagocytosis of microspheres by human neutrophils.Inflammation · 1990Article
- Surface phagocytosis and host defence in the peritoneal cavity during continuous ambulatory peritoneal dialysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the mechanism of surface phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN). Surface phagocytosis of unopsonized bacteria occurred, but was significantly enhanced by the presence of serum. The serum requirement was low, and a maximal effect occurred with serum concentrations of 0.25-0.5%. The opsonic effect of serum was not removed by heat inactivation of complement but was adsorbed, at low serum concentrations, by protein A, indicating that opsonin-dependent surface phagocytosis requires IgG but not C3. The requirement of opsonin-dependent surface phagocytosis for IgG was demonstrated further with purified IgG preparations as the sole opsonin. Activation of PMN by N-formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA) increased opsonin-independent surface phagocytosis by 47% and 66%, respectively, but had no effect on opsonin-dependent surface phagocytosis. Blockade of the PMN iC3b receptor (CR3), which has lectin-like properties, by a panel of monoclonal antibodies against the alpha- and beta-chains of CR3 did not inhibit the surface phagocytosis of opsonized or unopsonized S. aureus, and one antibody (NIMP-R10) enhanced opsonin-independent surface phagocytosis. These results indicate that the mechanism of surface phagocytosis is quite different to that observed in suspension assays. Opsonin-independent surface phagocytosis occurs and is enhanced by PMN activation, opsonin-dependent surface phagocytosis is dependent on IgG and not complement, and neither opsonin-independent nor -dependent surface phagocytosis proceeds through CR3.
Indexed as
Identifiers
2971611PMC1384995W183036528What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.