Evidence map›Paper›PMID 29715623›Full record

ArticleVirology2018

Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity.

Steven D Hatfield, Keith A Daniels, Carey L O'Donnell, Stephen N Waggoner, Raymond M Welsh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Enhanced development of functional human NK cells in NOD-scid-IL2rgFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  5. Article
  6. Targeting natural killer cells to enhance vaccine responses.Trends in pharmacological sciences · 2021
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Steven D HatfieldDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, ASC9-2014E, Worcester, MA 01605, USA.
Keith A DanielsDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, ASC9-2014E, Worcester, MA 01605, USA.
Carey L O'DonnellDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, ASC9-2014E, Worcester, MA 01605, USA.
Stephen N WaggonerCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, MLC 15012, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, 3230 Eden Ave, Cincinnati, OH 45267, USA.
Raymond M WelshDepartment of Pathology, University of Massachusetts Medical School, 368 Plantation Street, ASC9-2014E, Worcester, MA 01605, USA. Electronic address: Raymond.Welsh@umassmed.edu.
University of Massachusetts Chan Medical School · USCincinnati Children's Hospital Medical Center · US

Funding

T cell and transgenic core U19AI109858 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 2014 to 2018
$11.9M
A revolutionary vaccine approach to prevent HIV infection in substance abuseDP1DA038017 · NIDA · CINCINNATI CHILDRENS HOSP MED CTR · PI WAGGONER, STEPHEN N. · 2014 to 2018
$3.9M
NIAID NIH HHS U19 AI109858NIDA NIH HHS DP1 DA038017
6 · The paper itself

Abstract

Natural killer (NK) cells control antiviral adaptive immune responses in mice during some virus infections, but the universality of this phenomenon remains unknown. Lymphocytic choriomeningitis virus (LCMV) infection of mice triggered potent cytotoxic activity of NK cells (NK

Indexed as

Cytotoxicity, ImmunologicAdaptive ImmunityAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD69 AntigensCell DifferentiationGranzymesImmunity, HumoralInterferon Regulatory Factor-4Interferon Regulatory FactorsKiller Cells, NaturalLectins, C-TypeLymphocyte ActivationLymphocytic ChoriomeningitisAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensGranzymesInterferon Regulatory Factor-4Interferon Regulatory FactorsLectins, C-TypeNK Cell Lectin-Like Receptor Subfamily CPerforinCD4 T cellsInterferonIRF4LCMVNK cellsNKG2AVaccinia virus

Identifiers

PMID29715623
PMCPMC5971155
OpenAlexW2801411950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.