Evidence map›Paper›PMID 29715300›Full record

ArticlePLoS medicine2018

Public versus internal conceptions of addiction: An analysis of internal Philip Morris documents.

Jesse Elias, Yogi Hale Hendlin, Pamela M Ling

Abstract readComparative StudyHistorical Article
In one paragraph

Article in PLoS medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jesse EliasCenter for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0002-3250-3329
Yogi Hale HendlinCenter for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0002-1714-6132
Pamela M LingCenter for Tobacco Control Research and Education, University of California, San Francisco, San Francisco, California, United States of America.ORCID 0000-0001-6166-9347

Funding

ANALYSIS OF TOBACCO INDUSTRY DOCUMENTSR01CA087472 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2000 to 2018
$12.5M
Postdoctoral training in tobacco controlR25CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLANTZ, STANTON ARNOLD · 2006 to 2015
$5.4M
Understanding Smokeless Tobacco MarketingR01CA141661 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2009 to 2019
$5.4M
Postdoctoral training in tobacco controlT32CA113710 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2016 to 2020
$2.6M
NCI NIH HHS R01 CA087472NCI NIH HHS R01 CA141661NCI NIH HHS R25 CA113710NCI NIH HHS T32 CA113710
6 · The paper itself

Abstract

backgroundTobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris became the first major tobacco company to admit nicotine's addictiveness. Evolving definitions of addiction have historically affected subsequent policymaking. This article examines how Philip Morris internally conceptualized addiction immediately before and after this announcement. METHODS AND

findingsWe analyzed previously secret, internal Philip Morris documents made available as a result of litigation against the tobacco industry. We compared these documents to public company statements and found that Philip Morris's move from public denial to public affirmation of nicotine's addictiveness coincided with pressure on the industry from poor public approval ratings, the Master Settlement Agreement (MSA), the United States government's filing of the Racketeer Influenced and Corrupt Organizations (RICO) suit, and the Institute of Medicine's (IoM's) endorsement of potentially reduced risk products. Philip Morris continued to research the causes of addiction through the 2000s in order to create successful potentially reduced exposure products (PREPs). While Philip Morris's public statements reinforce the idea that nicotine's pharmacology principally drives smoking addiction, company scientists framed addiction as the result of interconnected biological, social, psychological, and environmental determinants, with nicotine as but one component. Due to the fragmentary nature of the industry document database, we may have missed relevant information that could have affected our analysis.

conclusionsPhilip Morris's research suggests that tobacco industry activity influences addiction treatment outcomes. Beyond nicotine's pharmacology, the industry's continued aggressive advertising, lobbying, and litigation against effective tobacco control policies promotes various nonpharmacological determinants of addiction. To help tobacco users quit, policy makers should increase attention on the social and environmental dimensions of addiction alongside traditional cessation efforts.

Indexed as

Attitude to HealthPublic OpinionTobacco IndustryBehavior, AddictiveDocumentationHistory, 20th CenturyHistory, 21st CenturyHumansNicotineSmokingUnited StatesNicotine

Identifiers

PMID29715300
PMCPMC5929514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.