ArticleOrganic & biomolecular chemistry2018
Chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside.
Article in Organic & biomolecular chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Enzymatic Synthesis of NADCurrent protocols · 2026Article
- Differential regulation of SIRT5 activity by reduced nicotinic acid riboside (NARH).RSC chemical biology · 2026Article
- Synthesis of Metabolites and Metabolite-like Compounds Using Biocatalytic Systems.Metabolites · 2023Review
- Nicotinamide riboside activates SIRT5 deacetylation.The FEBS journal · 2023Article
- Emerging Role of Nicotinamide Riboside in Health and Diseases.Nutrients · 2022Review
- Article
- Small Molecule Regulators Targeting NADCurrent medicinal chemistry · 2022Article
- Development of Second Generation Activity-Based Chemical Probes for Sirtuins.Molecules (Basel, Switzerland) · 2020Article
- Scalable syntheses of traceable ribosylated NADOrganic & biomolecular chemistry · 2019Article
- The chemistry of the vitamin B3 metabolome.Biochemical Society transactions · 2019Review
- Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives.Beilstein journal of organic chemistry · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
As a cofactor for numerous reactions, NAD+ is found widely dispersed across many maps of cellular metabolism. This core redox role alone makes the biosynthesis of NAD+ of great interest. Recent studies have revealed new biological roles for NAD+ as a substrate for diverse enzymes that regulate a broad spectrum of key cellular tasks. These NAD+-consuming enzymes further highlight the importance of understanding NAD+ biosynthetic pathways. In this study, we developed a chemo-enzymatic synthesis of isotopically labeled NAD+ precursor, nicotinamide riboside (NR). The synthesis of NR isotopomers allowed us to unambiguously determine that NR is efficiently converted to NAD+ in the cellular environment independent of degradation to nicotinamide, and it is incorporated into NAD+ in its intact form. The versatile synthetic method along with the isotopically labeled NRs will provide powerful tools to further decipher the important yet complicated NAD+ metabolism.
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Registered trials
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