ArticleOptics letters2018
Nanobomb optical coherence elastography.
Article in Optics letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Optimized ultrasound imaging of phase-change nanodroplets.Ultrasonics · 2026Article
- Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation.Biomedical optics express · 2025Article
- Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture.IEEE open journal of engineering in medicine and biology · 2025Article
- Nanobomb optical coherence elastography in multilayered phantoms.Biomedical optics express · 2023Article
- Noncontact longitudinal shear wave imaging for the evaluation of heterogeneous porcine brain biomechanical properties using optical coherence elastography.Biomedical optics express · 2023Article
- Newly developed gas-assisted sonodynamic therapy in cancer treatment.Acta pharmaceutica Sinica. B · 2023Review
- Review
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Deep Tissue Characterization with Optical Coherence Elastography: A Comparison of Different Methods.Materials (Basel, Switzerland) · 2022Article
- One-Pot, One-Step Synthesis of Drug-Loaded Magnetic Multimicelle Aggregates.Bioconjugate chemistry · 2022Article
- Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents.Medical physics · 2022Article
- Introduction to optical coherence elastography: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2022Article
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- Optical coherence tomography.Nature reviews. Methods primers · 2022Article
- Repetitive optical coherence elastography measurements with blinking nanobombs.Biomedical optics express · 2020Article
- Laser-induced elastic wave classification: thermoelastic versus ablative regimes for all-optical elastography applications.Journal of biomedical optics · 2020Article
- Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography.Biomedical optics express · 2019Article
- Polarization-sensitive optical coherence elastography.Biomedical optics express · 2019Article
- Microrheological quantification of viscoelastic properties with photonic force optical coherence elastography.Optics express · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Wave-based optical elastography is rapidly emerging as a powerful technique for quantifying tissue biomechanical properties due to its noninvasive nature and high displacement sensitivity. However, current approaches are limited in their ability to produce high-frequency waves and highly localized mechanical stress. In this Letter, we demonstrate that the rapid liquid-to-gas phase transition of dye-loaded perfluorocarbon nanodroplets ("nanobombs") initiated by a pulsed laser can produce highly localized, high-frequency, and broadband elastic waves. The waves were detected by an ultra-fast line-field low-coherence holography system. For comparison, we also excited waves using a focused micro-air-pulse. Results from tissue-mimicking phantoms showed that the nanobombs produced elastic waves with frequencies up to ∼9 kHz, which was much greater than the ∼2 kHz waves excited by the air-pulse. Consequently, the nanobombs enabled more accurate quantification of sample viscoelasticity. Combined with their potential for functionalization, the nanobombs show promise for accurate and highly specific noncontact all-optical elastography.
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