Evidence map›Paper›PMID 29714687›Full record

ArticleeLife2018

Synthetic hormone-responsive transcription factors can monitor and re-program plant development.

Arjun Khakhar, Alexander R Leydon, Andrew C Lemmex, Eric Klavins, Jennifer L Nemhauser

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Article
  2. Review
  3. CONSERVATION AND DIVERGENCE WITHIN THEbioRxiv : the preprint server for biology · 2026
    Article
  4. The Promise of Synthetic Biology for Redesigning Plant Architecture.International journal of molecular sciences · 2026
    Review
  5. Elucidating the design principles for engineering plant organ size.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Gibberellins: extending the Green Revolution.Journal of experimental botany · 2025
    Review
  15. The switch-liker's guide to plant synthetic gene circuits.The Plant journal : for cell and molecular biology · 2025
    Review
  16. Article
  17. Can a plant biologist fix a thermostat?The New phytologist · 2025
    Review
  18. Review
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arjun Khakhar *Department of Electrical Engineering, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-4676-6533
Alexander R LeydonDepartment of Biology, University of Washington, Seattle, United States.
Andrew C LemmexDepartment of Biology, University of Washington, Seattle, United States.
Eric KlavinsDepartment of Electrical Engineering, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-3805-5117
Jennifer L NemhauserDepartment of Biology, University of Washington, Seattle, United States.ORCID http://orcid.org/0000-0002-8909-735X

Funding

Control of protein degradation dynamics in the auxin responseR01GM107084 · NIGMS · UNIVERSITY OF WASHINGTON · PI NEMHAUSER, JENNIFER L · 2014 to 2022
$2.4M
Howard Hughes Medical Institute Faculty Scholars ProgramNIGMS NIH HHS R01 GM107084NIH HHS R01-GM107084
6 · The paper itself

Abstract

Developmental programs sculpt plant morphology to meet environmental challenges, and these same programs have been manipulated to increase agricultural productivity (Doebley et al., 1997; Khush, 2001). Hormones coordinate these programs, creating chemical circuitry (Vanstraelen and Benková, 2012) that has been represented in mathematical models (Refahi et al., 2016; Prusinkiewicz et al., 2009); however, model-guided engineering of plant morphology has been limited by a lack of tools (Parry et al., 2009; Voytas and Gao, 2014). Here, we introduce a novel set of synthetic and modular

Indexed as

Cellular ReprogrammingGene Expression Regulation, PlantPlant DevelopmentArabidopsisArabidopsis ProteinsPlant Growth RegulatorsArabidopsis ProteinsPlant Growth RegulatorsA. thalianaauxinCRISPR Cas9engineered developmentphyllotaxyphytohormoneplant biologysynthetic transcription factor

Identifiers

PMID29714687
PMCPMC5976440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.